OBJECTIVE Microminipigs are a novel animal model with extensive applications in laboratory studies owing, in part, to their extremely small body sizes. In this study, the relationship between swine leukocyte antigen (SLA) class II haplotype and body weight was evaluated in the Microminipig population. METHODS A total of 1,900 haplotypes, covering SLA class II haplotypes Lr-0.7, Lr-0.23, Lr-0....

The adipose tissue-derived hormone leptin regulates body weight homeostasis by decreasing food intake and increasing energy expenditure. The weight-reducing action of leptin is thought to be mediated primarily by signal transduction through the leptin receptor (LR) in the hypothalamus. We have used immunohistochemistry to localize LR-immunoreactive (LR-IR) cells in the rat brain using an antise...

In the literature, several numerical methods are proposed for solvingnth-order fuzzy linear differential equations. However, till now there areonly two analytical methods for the same. In this paper, the fuzzy Kolmogorov'sdifferential equations, obtained with the help of fuzzy Markov modelof piston manufacturing system, are solved by one of these analytical methodsand illustrated that the obtai...

We present a model and propose an approach to compute an approximate solution of Fully Fuzzy Linear System $(FFLS)$ of equations in which all the components of the coefficient matrix are either nonnegative or nonpositive. First, in discussing an $FFLS$ with a nonnegative coefficient matrix, we consider an equivalent $FFLS$ by using an appropriate permutation to simplify fuzzy multiplications. T...

BACKGROUND Severe hemorrhage is associated with the disruption of the endothelial glycocalyx (EG), a key component of the endothelium. The effects of blood components on the EG are unknown. The present study furthers our investigations into the effects of resuscitation with blood products on the skeletal muscle microcirculation of hemorrhaged rats, focusing on packed red blood cells (PRBCs) or ...

It has been reported that extracellular matrix (ECM) molecules regulate monocyte activation by binding with a 67 kDa nonintegrin laminin receptor (LR). As microgliosis is a pivotal factor in propelling the progress of chronic neurodegeneration in the brain, we hypothesized that LR may regulate the microgliosis and subsequent neurotoxicity. Using 1-methyl-4-phenylpyridinium (MPP+) -treated C57 m...

Left-right (LR) asymmetry is essential for organ development and function in metazoans, but how initial LR cue is relayed to tissues still remains unclear. Here, we propose a mechanism by which the Drosophila LR determinant Myosin ID (MyoID) transfers LR information to neighboring cells through the planar cell polarity (PCP) atypical cadherin Dachsous (Ds). Molecular interaction between MyoID a...