BACKGROUND Switching a thymidine analogue to a non-thymidine analogue or changing to a nucleoside-sparing regimen has been shown to partially reverse peripheral lipoatrophy. The current study evaluated both approaches. METHODS Subjects at 15 AIDS Clinical Trial Group sites receiving thymidine analogue stavudine- or zidovudine-containing regimens with plasma HIV RNA < or =500 copies/mL and lip...

BACKGROUND The risk of cardiovascular disease in human immunodeficiency virus (HIV)-infected patients is an increasing concern. We studied the changes in vascular properties after the initiation of combination antiretroviral therapy (cART) as well as the contribution of different drug classes. METHODS cART-naive men were randomized to receive either lopinavir/ritonavir (LPV/r) plus zidovudine...

A model order reduction method is proposed for models of aeroservoelastic vehicles in the linear parameter-varying (LPV) systems framework, based on state space interpolation of modal forms. The dynamic order of such models is usually too large for control synthesis and implementation since they combine rigid body dynamics, structural dynamics and unsteady aerodynamics. Thus, model order reduct...

ABSTRACT: System or process identification is a mathematical modeling of systems (processes) from test or experimental data. Process models obtained from identification process can be used for process simulation, analysis, design of safety systems and control systems for the process. This paper presents the Linear Parameter Varying (LPV) modeling of 210MW Industrial Coal Fired Boiler which is c...

Neste número do Jornal de Pediatria, Silveira et al. investigaram fatores de risco para o desenvolvimento de leucomalácia periventricular (LPV) emuma coorte de recém-nascidos de muito baixo peso (RNMBP). Um número significativamentemaior de recém-nascidos comLPVapresentaramsepse documentada e/ou foram mantidos sob ventilação por mais de 24 horas. Esse estudo bem delineado acrescenta evidência d...

Lopinavir (LPV), an antiretroviral protease inhibitor frequently prescribed in HIV-positive pregnancies, is a substrate of Abcb1 and Abcc2. As differences in placental expression of these transporters were seen in Pregnane X Receptor (PXR) -/- mice, we examined the impact of placental transporter expression and fetal PXR genotype on the fetal accumulation of LPV. PXR +/- dams bearing PXR +/+, P...

This study was performed to examine the role of transglutaminase 2 (TG2) in ventilator-induced lung injury (VILI). C57BL/6 mice were divided into six experimental groups: 1) control group; 2) lipopolysaccharide (LPS) group; 3) lung protective ventilation (LPV) group; 4) VILI group; 5) VILI with cystamine, a TG2 inhibitor, pretreatment (Cyst+VILI) group; and 6) LPV with cystamine pretreatment (C...

This paper is one of two joint papers, each presenting and utilizing a different representation of a feedforward neural network for controller design. Here a neural state-space model is transformed into a linear fractional transformation (LFT) representation to obtain a discrete-time quasi-linear parameter-varying (LPV) model of a nonlinear plant, whereas in the joint paper (Abbas and Werner [2...

This paper presents a new methodology for the modeling and control of power systems based on an uncertain polytopic linear parameter-varying (LPV) approach using parameter set mapping with principle component analysis (PCA). An LPV representation of the power system dynamics is generated by linearization of its differential-algebraic equations about the transient operating points for some given...

This paper demonstrates the application of the linear parameter-varying (LPV) framework to control a copolymerization reactor. An LPVmodel representation is first developed for a nonlinear model of the process. The LPV model complexity in terms of the model order and the number of scheduling variables is then reduced by truncating those system states that have insignificant direct influence on ...