Advances in enzyme stabilization and immobilization make the use of enzymes for industrial applications increasingly feasible. The lactoperoxidase (LPO) system is a naturally occurring enzyme system with known antimicrobial activity. Stabilized LPO and glucose oxidase (GOx) enzymes were combined with glucose, potassium iodide, and ammonium thiocyanate to create an anti-fungal formulation, which...

AIM After acute spinal cord injury (SCI), a large number of axons are lost by a cascade of pathophysiological events known as a secondary injury. The main aim of the current study was to investigate the potential neuroprotective effects of curcumin on lipid peroxidation (LPO), neurological function, and ultrastructural findings after SCI. MATERIAL AND METHODS Forty adult Wistar albino rats we...

The aging is one of the factors that cause decrease in the antioxidant capacity. Likewise, it has been proposed that subjects exposed permanently to air pollution develop deficient antioxidant capacity to oxidative stress (OxS). This study aimed to analyze the antioxidant capacity against elevated lipid peroxides in healthy elderly of Mexico City. 105 adults (44 ± 10.8 years) and 126 elderly su...

Recent seismological observations show patches of highly anisotropic regions in the bottom of an otherwise isotropic lower mantle 1-4. These regions likely correspond to paleo-subduction or plume upwelling, but the exact cause for anisotropy is unknown. Both shape-preferred orientation (SPO) of elastically heterogenous materials 5 and lattice-preferred orientation (LPO) 6-8 have been proposed. ...

Recent studies have revealed that the human and nonrodent mammalian airway mucosa contains an oxidative host defense system. This three-component system consists of the hydrogen peroxide (H2O2)-producing enzymes dual oxidase (Duox)1 and Duox2, thiocyanate (SCN−), and secreted lactoperoxidase (LPO). The LPO-catalyzed reaction between H2O2 and SCN− yields the bactericidal hypothiocyanite (OSCN−) ...

STUDY OBJECTIVE Neutrophils are involved in acute lung injury during ARDS via several mechanisms. This study focuses on neutrophil-derived oxidative stress. Hypochlorite is a major neutrophil-derived oxidant. This study characterizes hypochlorite-induced acute changes in pulmonary circulation and the involvement of tissue lipid peroxidation (LPO) and reduced glutathione (rGSH) depletion. METH...

34 The preoptic hypothalamus is implicated in sleep regulation. Neurons in the median 35 preoptic nucleus (MnPO) and the ventrolateral preoptic area (VLPO) have been 36 identified as potential sleep regulatory elements. However, the extent to which MnPO 37 and VLPO neurons are activated in response to changing homeostatic sleep regulatory 38 demands is unresolved. To address this question, we c...

Zhang C, Adamos C, Oh MJ, Baruah J, Ayee MA, Mehta D, Wary KK, Levitan I. oxLDL induces endothelial cell proliferation via Rho/ROCK/Akt/p27 signaling: opposite effects of oxLDL and cholesterol loading. Am J Physiol Cell Physiol 313: C340 –C351, 2017. First published July 12, 2017; doi:10.1152/ ajpcell.00249.2016.—Oxidized modifications of LDL (oxLDL) play a key role in the development of endoth...

Oxidative stress and lipid peroxidation (LPO) are involved in the pathogenesis of several human diseases, including cancer. LPO products react with proteins and with DNA bases to form exocyclic DNA adducts of different size and high mutagenic potency. Ethenoadducts are removed mainly by Base Excision Repair (BER) pathway, while bulky adducts of LPO products by Nucleotide Excision Repair (NER). ...

Antioxidative potential of Aloe was studied in mice exposed to different doses of gamma radiation. In this study, adult male Swiss albino mice were divided in six groups (I, II, III, IV, V and VI). Group I and II contained sham irradiated (normal) and Aloe alone treated animals respectively. Each group from III-VI contained an experimental set in which Aloe extract was administered orally at th...