Primary angle-closure glaucoma (PACG) is a major form of glaucoma in Asia. It is a leading cause of blindness worldwide. Laser peripheral iridotomy (LPI) is the standard firstline intervention in both acute and chronic forms. It is successful in preventing recurrence of acute attacks and virtually eliminates the risk of an acute attack in the fellow eye. Peripheral iridotomy eliminates pupillar...

Labile iron in hemosiderotic plasma and tissue are sources of iron toxicity. We compared the iron chelators deferoxamine, deferiprone and deferasirox as scavengers of labile iron in plasma and cardiomyocytes at therapeutic concentrations. This comprised: chelation of labile plasma iron (LPI) in samples from thalassemia patients; extraction of total cellular iron; accessing labile iron accumulat...

This paper presents a novel low probability of intercept (LPI) optimization framework in radar network by minimizing the Schleher intercept factor based on minimum mean-square error (MMSE) estimation. MMSE of the estimate of the target scatterer matrix is presented as a metric for the ability to estimate the target scattering characteristic. The LPI optimization problem, which is developed on t...

| Frequency-hopping is considered to be an eeective method for combating active jamming in military radio systems. To further improve the performance , so-called adaptive frequency-hopping (AFH), which uses an adaptively selected pool of the \best" hopping-frequencies for the communication, has been proposed. In this paper, we examine the low probability of intercept (LPI) performance of such a...

GPR55 is a G protein-coupled receptor recently shown to be activated by certain cannabinoids and by lysophosphatidylinositol (LPI). However, the physiological role of GPR55 remains unknown. Given the recent finding that the cannabinoid receptors CB(1) and CB(2) affect bone metabolism, we examined the role of GPR55 in bone biology. GPR55 was expressed in human and mouse osteoclasts and osteoblas...

We have recently shown that the G protein-coupled receptor 55 (GPR55) mediates intracellular effects of cannabinoids and other, non-cannabionid, ligands in addition to the classical cannabinoid 1 (CB1R) and 2 (CB2R) receptors. Here we show that the presence of either CB1R or CB2R alters the signaling pathways of GPR55. HEK-293 cells stably expressing either the GPR55 receptor alone or in combin...

Although L-arginine is the only substrate for nitric oxide (NO) production, no studies have yet been reported on the effect of an L-arginine deficiency on vascular function in humans. Lysinuric protein intolerance (LPI) is a rare autosomal recessive defect of dibasic amino acid transport caused by mutations in the SLC7A7 gene, resulting in an L-arginine deficiency. Vascular endothelial function...

To improve the performance of frequency-hopping systems on interference-limited HF channels, so-called adap-tive frequency-hopping (AFH), which uses an adaptively selected pool of the \best" hopping-frequencies for the communication , has been proposed. In this paper, we extend the adaptivity of the AFH scheme by adjusting the transmitted power on each channel individually and by adap-tively ch...

PURPOSE To compare laser peripheral iridotomy (LPI) with trabeculectomy as an initial treatment for primary angle-closure glaucoma (PACG) with peripheral anterior synechiae (PAS) ≥ 6 clock hours. METHODS Patients were drawn from two randomized controlled trials. 38 eyes of 38 patients (PAS ≥ 6 clock hours) were treated with LPI (group 1) while 111 eyes of 111 PACG patients (PAS ≥ 6 clock hour...