This thesis is based on the following original articles, which are referred to in the text by their Roman numerals. acid content of LDL and lipoprotein metabolism in combined hyperlipidemia and primary moderate hypercholesterolemia. acid content of LDL and its relation to lipid concentrations and metabolism of LDL and cholesterol. Submitted. increases the sialic acid content of LDL in hyperchol...

OBJECTIVE The contribution of visceral fat accumulation to the development of coronary heart disease was previously reported, but the relation between visceral fat accumulation and serum lipoprotein subclasses was unknown. METHODS AND RESULTS We examined the relation of lipoprotein subclasses with visceral fat accumulation in 62 male subjects (aged 22 to 67 years) with visceral fat syndrome o...

A child showed a type IIb lipoprotein pattern and triglyceride-enriched cutaneous xanthomas before 1 year of age. The proband and 9 of 18 relatives had elevated plasma levels of low density lipoprotein (LDL) B protein; of these nine relatives, four had elevated LDL of increased density while five had elevated LDL of normal density. Compared with normal LDL, LDL of increased density had less cho...

South Asians have a higher incidence of coronary heart disease (CHD) than individuals of European descent1 and present with first acute myocardial infarction at younger ages.2 In the study by Joshi et al,2 among the several CHD risk factors that differentiated native South Asians from those living in other countries was an increase in abdominal obesity. Of interest in this context is the sugges...

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme that plays a key role in regulating the circulating low density lipoprotein cholesterol (LDL-C). Among PCSK9 variants, while gain-of-function mutations aggravate degradation of LDL receptors, leading to familial hypercholesterolemia (FH), whereas loss-of-function increase receptor levels, lower and prevent coronary heart disease...

Objective: To assess the oxidized low density lipoprotein (ox-LDL) to (LDL) ratio as an indicator of subclinical atherosclerosis in haemodialysis patients Methodology: This case control study was carried out at Jinnah Post Graduate Medical Center Karachi, from January December 2018. The were selected dialysis center (group B) whereas controls recruited normal healthy population A). access statu...

To assess the potential of various plasma lipoprotein classes to contribute to the lipid content of the arterial intima, influx and efflux of these plasma lipoprotein fractions into and from the intima of human carotid arteries were measured in vivo. While low density lipoprotein (LDL) is known to transfer from plasma into the arterial wall, there is less information on the atherogenic potentia...

1INTRODUCTION Tumor cells have a very distinctive metabolism. Several previous studies have considered the metabolic changes that take place in the host after tumor implantation. Metabolic abnormalities arising from malnutrition and malignancy are seen in animals or patients with cancer cachexia. Various cancers affect the lipid metabolism.1-7) Rats subcutaneously implanted with the ascites hep...

The purpose of this study was to determine the role Oxidized Low Density Lipoprotein (OX LDL) promotes insufficient autophagy and apoptosis ovarian granulosa cells through regulation Reactive Oxygen Species (ROS) mediated PI3K Akt/mTOR pathway.