Megakaryocytes (MKs) undergo an endomitotic cell cycle, leading to polyploidy. We examined the expression of the flavoproteins and oxidative stress-promoting enzymes, NADPH oxidases (Nox's), in MKs because of their known role in promoting the cell cycle. Although the expression of Nox isoforms varies between cell types, they are induced at the mRNA level by mitogenic stimuli. Western blotting o...

Could titanium-clean air be how advertisers one day try to sell us the virtues of paint or even clothing that reduces the pollution caused by automobiles? The technology behind such products involves the well-known ability of titanium dioxide (TiO2) to photocatalytically split water to form hydroxyl and peroxyl radicals, a reaction that has already been harnessed to make self-cleaning windows. ...

BACKGROUND Ambient monitoring data show spatial gradients in ozone (O3) across urban areas. Nitrogen oxide (NOx) emissions reductions will likely alter these gradients. Epidemiological studies often use exposure surrogates that may not fully account for the impacts of spatially and temporally changing concentrations on population exposure. OBJECTIVES We examined the impact of large NOx decrea...

There is considerable interest in developing fuel-flexible, low emissions turbines for power generation. One approach is based on burning a variety of lean premixed fuels with relatively low flame temperatures. Such flames can be stabilized in a low swirl burner configuration, for example, using a variety of fuels such as pure hydrogen and hydrogen-seeded hydrocarbon mixtures. However, many hyd...

The pulsed polarization technique on solid electrolytes is based on alternating potential pulses interrupted by self-discharge pauses. Since even small concentrations of nitrogen oxides (NOx) in the ppm range significantly change the polarization and discharge behavior, pulsed polarization sensors are well suited to measure low amounts of NOx. In contrast to all previous investigations, planar ...

2017 and 2020 will represent major milestones for the light vehicle Diesel engine in Europe and other regions that are committed to WLTP. The Diesel engines’ position as the most efficient prime mover and the need for it to be included in a balanced and aggressive CO2 roadmap is not really disputed. Diesel however faces significant challenges in WLTC / RDE to deliver low ‘real world’ engine out...

Employing in vitro selection techniques, we have generated biostable RNA-based compounds, so-called Spiegelmers, that specifically bind n-octanoyl ghrelin, the recently discovered endogenous ligand for the type 1a growth hormone secretagogue (GHS) receptor. Ghrelin is a potent stimulant of growth hormone release, food intake, and adiposity. We demonstrate that our lead compound, L-NOX-B11, bind...