The current study is to validate spectrophotometric method with UV detection for identification and determination of losartan potassium in respect of analytical parameters accuracy, precision, linearity. This simple, sensitive, accurate, economical and reproducible UV Spectrophotometric method can be applied for the determination of Losartan Potassium (LP) tablet dosage forms. The method is bas...

We describe a method for the measurement of protein-bound malondialdehyde with the thiobarbituric acid reaction in human plasma using second-derivative spectrophotometry. Calibration was done by spectrum height measurement from the baseline at 532 nm. The data were compared with those obtained by using conventional absorbance and fluorimetric measurements. The results were linear from 0.2 to 80...

Simultaneous determination of Dimenhydrinate (DIM) and Cinnarizine (CIN) binary mixture with simple procedures were applied. Three ratio manipulating spectrophotometric methods were proposed. Normalized spectrum was utilized as a divisor for simultaneous determination of both drugs with minimum manipulation steps. The proposed methods were simultaneous constant center (SCC), simultaneous deriva...

Mexidol (3-hydroxy-6-methyl-2-ethylpyridine succinate) is a drug that exhibits neuroprotective, antihypoxic, anti-ischemic, nootropic, anti-stress and geroprotective effects can suppress or slow down oxidation reactions. Оbjective: to develop selective simple method for assessing the content of mexidol in tablets. Materials methods. The objects study were tablets 0.125 g. Derivative spectrophot...

ACE inhibition reduces plasminogen activator inhibitor-1 (PAI-1), a risk factor for myocardial infarction, whereas the effect of angiotensin receptor antagonism on PAI-1 is uncertain. The present study compares the time course of effects of ACE inhibition and angiotensin type 1 (AT1) receptor antagonism on morning plasma PAI-1 antigen. Blood pressure and endocrine, metabolic, and fibrinolytic v...

UV, first, second and third derivative spectrophotometric methods have been developed for the determination of ezetimibe in pharmaceutical formulation. The solutions of standard and sample were prepared in methanol. For the first method, UV spectrophotometry, the quantitative determination of the drug was carried at 233 nm and the linearity range was found to be 6-16 mug/ml. For the first, seco...