Oral lorazepam is a commonly used premedicant both locally and abroad. We studied its effect on recovery time after minor gynaecological procedures. The results showed a significant prolongation of recovery time.

Mr. G., a 38 year old married male fiom a urban middle socioeconomic nuclear family, employed as a bank officer, came to the Psychiatry Walk in clinic at National institute of Mental Health and Neurosciences with the complaint of not being able to discontinue taking lorazepam for one and a half years. There was no contributory family or any other past history. After a job transfer about 2 years...

The acid-base equilibrium of lorazepam was studied by means of potentiometry andmultiwavelengths spectrophotometry. The stoichiometric equilibrium constants were determinedat 25 °C and constant ionic strength 0.1 mol L-1 (NaCl). The acidity constants pK1=1.58±0.05and pK2=11.67±0.07 were found by potentiometry, and pK1=1.54±0.02 and pK2=11.61±0.03 bymulti-wavelengths spectrophotometry. Potentiom...

INTRODUCTION Many drugs are unavailable in suitable oral paediatric dosage forms, and pharmacists often have to compound drugs to provide paediatric patients with an acceptable formulation in the right dose. Liquid formulations offer the advantage of dosing flexibility and ease of administration to young patients, but drug substances often show poor aqueous solubility. The objective of this wor...

Aims Catatonia is a psychomotor state characterised by multitude of clinical signs such as abnormal movements, mutism and withdrawal. This condition usually associated with medical psychiatric aetiologies potential being life-threatening. It managed benzodiazepines, the commonest lorazepam. In this piece work, we would like to focus on principles care that should be considered whilst managing p...

and commentary also appear in ACP Journal Club and a modified version of the abstract appears in Evidence-Based Nursing. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . For correspondence: Dr K Prasad, All India Institute of Medical Sciences, New Delhi, India. [email protected] Source of funding: no external f...

BACKGROUND Functional neuroimaging may elucidate the pathophysiologic features of anxiety disorders and the site of action of anxiolytic drugs. A large body of evidence suggests that the amygdala and associated limbic structures play a critical role in the expression of anxiety and may be treatment targets for anxiolytic drugs. OBJECTIVE To determine whether lorazepam dose-dependently attenua...