No previous reports are available about the potential dramatic effects resulting from the combination of acquired long QT interval not associated to bradycardia and myocardial ischemia. We report the case of a man that during acute necrotic pancreatitis presented QT interval prolongation without bradycardia, TdP, and two episodes of cardiac arrest. A coronary angiogram revealed a subocclusive s...

methadone is a synthetic opioid used as the standard treatment for narcotics dependence.cyp3a is the major enzyme to metabolize methadone. long qt syndrome and secondary tdp (a polymorphic ventricular tachycardia) to methadone is generally rare, but in the past few years, gained attention of many scientists as a potentially fatal complications caused by methadone. interact  with voltage-depende...

ramadan fasting is one of the most important religious duties of muslims, that its effect on the heart has not been determined yet. our objective was to evaluate the effect of ramadan fasting on ventricular repolarization as assessed by qt interval, corrected qt interval, qt dispersion or corrected qt dispersion. sixthy healthy subjects aged 20 to 35 years were dispersion included in this study...

The patient was a 71-year-old female with Torsade de Pointes (TdP) associated with idiopathic long QT syndrome. TdP and polymorphic nonsustained VT were frequently observed at bedside and an electrophysiologic study was performed. The QT (and QTU) interval was abnormally prolonged, and alteration of the QT interval was also recorded on the electrocardiogram. Monophasic action potential (MAP) fr...

1 Jervell A, Lange-Nielse F. Congenital deaf-mutism, functional heart disease with prolongation of the QT interval and sudden death. Am Hearty 1957;54:59-68. 2 Schwartz PJ. Idiopathic long QT syndrome: Progress and questions. Am Hearty 1985;109:399-41 1. 3 Gillette PC, Garson A. Ventricular arrhythmias. Pediatric arrhythmias: electrophysiology and pacing. Philadelphia: WB Saunders, 1990:468-72....

BACKGROUND- Homozygous or compound heterozygous mutations in KCNQ1 cause Jervell and Lange-Nielsen syndrome, a rare, autosomal-recessive form of long-QT syndrome characterized by deafness, marked QT prolongation, and a high risk of sudden death. However, it is not understood why some individuals with mutations on both KCNQ1 alleles present without deafness. In this study, we sought to determine...

BACKGROUND Little is known about the prevalence and prognostic significance of long QT interval among patients with chest pain during the acute phase of suspected cardiovascular injury. OBJECTIVES Our aim was to investigate the prevalence and prognostic significance of long QT interval among patients presenting to the emergency department (ED) with chest pain using an optimum QT rate correcti...