Gliomas classified as grade II by the World Health Organization (WHO) include astrocytomas, oligodendrogliomas, and mixed oligoastrocytomas. This heterogeneous group of conditions is associated with a more favorable prognosis and longer-term survival than high-grade gliomas (HGGs). Neurosurgical resection and radiation therapy improve survival in symptomatic, progressive, or high-risk grade II ...

The Kenya Ophthalmic Programme (KOP) is a Ministry of Health (MOH) programme receiving administrative support from the Kenya Society for the Blind (KSB). It started as a small project in 1956 but has grown into a major National Programme rendering comprehensive eye care (CEC) through a network of about 70 Government and NGO static and outreach service delivery points scattered all over the coun...

(Anti)self-dual solutions of the scale invariant SO±(4) ∼ SU(2) gauged Grassmanian model are sought. A stronger (anti)selfduality condition for this system is defined, referred to as strong self-duality, and Spherically symmetric solutions of this strong (anti)self-duality equations are found in closed form. It is verified that these are the only solutions of the strong (anti)self-duality equat...

The purpose of this paper is to introduce and provide context for the issues to be addressed at the North American Workshop on Risk Assessment and Children’s Environmental Health. It is not intended to be a comprehensive review of the current state of the science nor debate. This paper was prepared by the secretariat of the Commission on Environmental Cooperation (CEC). The views presented here...

The Royal Society took as one of its patron saints Francis Bacon, who envisaged the great calling of science as acting as a means of effecting ‘ the relief of man’s estate ’ through a partnership between philosophers and politicians. The object of this paper is to examine the extent to which this goal was realized from the time of the Society’s foundation until the end of the eighteenth century...

Anaplastic oligodendrogliomas (AOs) are rare brain tumors responsive to chemotherapy with procarbazine, lomustine (CCNU) and vincristine (PCV), especially when harboring 1p19q codeletion. However, with the emergence of temozolomide as an easier to administer and less toxic alternative regimen, PCV fell out of favor. Now, long-term results of two Phase III studies conceived in the 1990s, Radiati...

Sublethal doses of irradiation enhance the invasiveness of human malignantglioma cells. This can be inhibited by subtoxic concentrations of temozolomide (TMZ) but not by lomustine. Antagonism of irradiation-induced motility by TMZ is associated with the prevention of irradiation-induced alpha(v)beta(3)-integrin, matrix metalloproteinase-2 and MT1-matrix metalloproteinase-expression. Irradiation...

An 8-year-old neutered female Cavalier King Charles spaniel was evaluated for progressing right forelimb lameness. Magnetic resonance imaging revealed that the right-side radial nerves and the caudal brachial plexus were swollen. The histological and molecular biological diagnosis by partial biopsy of the C8 spinal nerve was T-cell lymphoma. Coadministration of lomustine and irradiation was sta...

A miniature dachshund aged 9 years and 7 months with a history of polyuria/polydipsia and depression was referred. General physical and neurological examinations revealed no obvious abnormalities. MRI of the brain revealed a large space-occupying lesion in the left frontal lobe. This was surgically removed and pathologically diagnosed as a primitive neuroectodermal tumor (PNET). Although the cl...