It is generally accepted that the avidity of TCR for self Ag/MHC determines the fate of immature thymocytes. However, the contribution of the quantity of TCR signal to T cell selection has not been well established, particularly in vivo. To address this issue, we analyzed DO-TCR transgenic CD3zeta-deficient (DO-Tg/zetaKO) mice in which T cells have a reduced TCR on the cell surface. In DO-Tg/ze...

Warehouse location selection is a multi-criteria decision problem including both quantitative and qualitative criteria and has a strategic importance for many companies. The conventional approaches to warehouse location selection problem tend to be less effective in dealing with the imprecise or vague nature of the linguistic assessment. Under many situations, the values of the qualitative crit...

The concept of site selection has received extensive attention throughout history. Although plant location decision issues have always been important to US manufacturing firms, the impact of global competition has increased recognition of their importance. To successfully compete globally, manufacturers must have an effective global supply chain infrastructure, which requires effective communic...

This paper proposes fuzzy multi-criteria decision-making approach integrated with fuzzy real option value theory. The applicability of the proposed method was shown on a real-world supermarket location selection problem. Based on the interviews with the experts, the evaluation criteria for retail location selection were identi ̄ed. Then the network for fuzzy analytic network process (ANP) method...

One of the problems studied in human-computer interaction (HCI) research is the design of interfaces that improve user information selection and processing performance. Based on prior research findings this study proposes that information selection can be improved by using multiple, supplementary cues to encode information in interface design. The research is motivated by cue-summation theory. ...

The facility location selection, which is one of the important activities in strategic planning for a wide range of private and public companies, is a multi-criteria decision making problem including both quantitative and qualitative criteria. Traditional methods for facility location selection can not be effectively handled because information can not be represented by precise information unde...

Previous studies of visually responsive neurons in the frontal eye fields have identified a selection process preceding saccades during visual search. The goal of this experiment was to determine whether the selection process corresponds to the selection of a conspicuous stimulus or to preparation of the next saccade. This was accomplished with the use of a novel task, called search-step, in wh...