Poor penetration of vancomycin into Central Nervous System (CNS) can lead to treatmentfailure. The aim of this study was to evaluate and compare CSF concentration and serumpharmacokinetics of high dose vancomycin by continuous infusion vs. intermittent infusion inpost neurosurgical meningitis patients. Twenty patients were divided into two groups. Patientsin intermittent infusion group received...

objective(s) theophylline, a xanthenes derivative, is still widely used as an effective bronchodilator in the management of asthmatic patients. it is used both as a prophylactic drug and to prevent acute exacerbations of asthma. the aim of study was to formulate and evaluate effect of the microencapsulation of theophylline loaded nanoparticles on the reduction of burst release. materials and me...

Primary load-bearing members used in glass structures, such as columns consisting of panels, are frequently subjected to in-plane loading. Its allowable stress for safety design appears be a significant subject. By analyzing the results static (without repeated loading) and cycling compression loading tests, authors explore mechanical features failure mechanism tempered panels subjective loadin...

fiber metal laminates (fmls) are new composite materials consisting of thin metal layers and high strength composite layers. arall (aramid aluminum laminate) is a family of the fml that consists of thin aluminum sheets along with kevlar/epoxy composite layers. this material has many advantages such as light weight, excellent corrosion, fatigue and impact resistance. since, arall is a new materi...

due to high surface-to-volume ratio of nanoscale structures, surface stress effects have a significant influence on their behavior. in this paper, a two-dimensional problem for an elastic layer that is bonded to a rigid substrate and subjected to an inclined concentrated line load acting on the surface of the layer is investigated based on gurtin-murdoch continuum model to consider surface stre...

The SiO2 supported cobalt-iron nano catalysts were prepared by the sol-gel method. This research investigated the effects of (Co/Fe) wt.%, different Co/Fe ratio at different temperature and loading of KCl wt.% for Fisher-Tropsch synthesis (FTS). The results were showed that the catalyst containing 50 wt.% (Co/Fe)/SiO2 (Co/Fe ratio is 70/30) which promoted with 0.6 wt.% KCl is an optimal nano ca...

This paper presents emergy assessment of biodiesel production in Brazil using conventional, organic and agroecological grown soybean. For the conventional soybean biodiesel the indicators are: Transformity: 5.05E+05 seJ J; Renewability: 24.1%; Emergy yield ratio: 1.40; Environmental loading ratio: 3.15. These values indicate high demand of non renewable resources and low sustainability degree, ...

The effect of 12 h road transportation on some basic blood cells and the modulating role of ascorbic acid were investigated in 40 adult Red Sokoto goats during the hot dry season. The animals were divided into two groups, GI (experimental; n = 20) and GII (control; n = 20). Group 1 was administered with ascorbic acid (AA) per os at a dosage rate of 100 mg/kg body weight, while GII was given 10 ...

BACKGROUND No data exist about the impact of high residual platelet reactivity (HRPR) after clopidogrel loading on long-term clinical outcome in patients undergoing drug-eluting stent (DES) implantation for unprotected left main disease (ULMD). METHODS AND RESULTS Consecutive patients who underwent percutaneous coronary intervention for ULMD had prospective platelet reactivity assessment by l...

OBJECTIVES A protocol was designed to produce albumin-coated microbubbles (MBs) loaded with functionalized polylactide (PLA) nanoparticles (NPs) for future drug delivery studies. METHODS Microbubbles resulted from the sonication of 5% bovine serum albumin and 15% dextrose solution. Functionalized NPs were produced by mixing fluorescent PLA and PLA-polyethylene glycol-carboxylate conjugates. N...