نتایج جستجو برای: lncrna

تعداد نتایج: 6925  

2018
Mingyu Du Teng Huang Jing Wu Jia-Jia Gu Nan Zhang Kai Ding Lu-Xi Qian Zhi-Wei Lu Wen-Jun Zhang Xiao-Kang Tian Xia He Li Yin

Long non-coding RNAs (lncRNAs) have been reported to perform significant roles in cancer development and progression. Our research has found that a novel lncRNA n326322 was higher in nasopharyngeal carcinoma (NPC) cells. Moreover, the gain and loss of functional approaches revealed that the overexpression of lncRNA-n326322 promoted NPC cell proliferation and invasion, whereas the downregulation...

Journal: :Genetics and molecular research : GMR 2015
W Q Song W Q Gu Y B Qian X Ma Y J Mao W J Liu

The aim of this study was to identify long non-coding RNA (lncRNA) associated with osteogenic differentiation from mesenchymal stem cells (MSCs) using high-throughput RNA sequencing (RNA-Seq) data. RNA-Seq dataset was obtained from the European Bioinformatics Institute (accession No. PRJEB4496), including two replicates each for immortalized mesenchymal stem cells iMSC#3 cultured in growth medi...

2016
Jinliang Liu Gong Cheng Haiwei Yang Xiaheng Deng Chao Qin Lixin Hua Changjun Yin

Increasing evidence implicates long noncoding RNAs (lncRNAs), a class of noncoding RNAs >200 nucleotides in length, in the development of cancer. However, the mechanism underlying the effects of lncRNAs in prostate cancer (PCa) remains to be elucidated. The present study aimed to investigate the role of lncRNA‑THBS4‑003 in the pathogensis of PCa. In the present study, a microarray containing 8,...

2018
Mu-Lin Liu Qiao Zhang Xiao Yuan Long Jin Li-Li Wang Tao-Tao Fang Wen-Bin Wang

AIM To investigate the role of long noncoding RNA (lncRNA) RP4 in colorectal cancer. METHODS Lentivirus-mediated lncRNA RP4 overexpression and knockdown were performed in the colorectal cancer cell line SW480. Cell proliferation, tumor growth, and early apoptosis were evaluated by a cell counting kit-8 assay, an in vivo xenograft tumor model, and annexin V/propidium iodide staining, respectiv...

2012
Satish Sati Sourav Ghosh Vaibhav Jain Vinod Scaria Shantanu Sengupta

A major fraction of the transcriptome of higher organisms comprised an extensive repertoire of long non-coding RNA (lncRNA) which express in a cell type and development stage-specific manner. While lncRNAs are a proven component of epigenetic gene expression modulation, epigenetic regulation of lncRNA itself remains poorly understood. Here we have analysed pan-genomic DNA methylation and histon...

2013
Geng Chen Ziyun Wang Dongqing Wang Chengxiang Qiu Mingxi Liu Xing Chen Qipeng Zhang Guiying Yan Qinghua Cui

In this article, we describe a long-non-coding RNA (lncRNA) and disease association database (LncRNADisease), which is publicly accessible at http://cmbi.bjmu.edu.cn/lncrnadisease. In recent years, a large number of lncRNAs have been identified and increasing evidence shows that lncRNAs play critical roles in various biological processes. Therefore, the dysfunctions of lncRNAs are associated wi...

2017
Yu-Hao Zhao Tie-Feng Ji Qi Luo Jin-Lu Yu

Defects in hippocampal synaptic plasticity and disorders of memory and learning are the central nervous system complications of diabetes mellitus (DM). Here, we used a streptozotocin-induced rat DM model to investigate the effects of long non-coding RNA H19 (lncRNA H19) on learning and memory and apoptosis of hippocampal neurons, and the involvement of the Wnt signaling. Our data demonstrate th...

Journal: :International journal of environmental research and public health 2016
Lei Hu Qiao-Li Lv Shu-Hui Chen Bao Sun Qiang Qu Lin Cheng Ying Guo Hong-Hao Zhou Lan Fan

Dysregulated long noncoding RNAs (lncRNAs) have been found in human diseases, especially in cancer. Emerging evidence indicates that dysregulated lncRNAs are implicated in tumorigenesis and cancer progression. LncRNA AB073614 characterized as a new candidate lncRNA promotes the development of ovarian cancer. However, the role of lncRNA AB073614 in human gliomas remains unknown. The expression o...

Journal: :RNA 2014
Rory Johnson Roderic Guigó

Our genome contains tens of thousands of long noncoding RNAs (lncRNAs), many of which are likely to have genetic regulatory functions. It has been proposed that lncRNA are organized into combinations of discrete functional domains, but the nature of these and their identification remain elusive. One class of sequence elements that is enriched in lncRNA is represented by transposable elements (T...

2018
Li Ling Zhen Tan Changning Zhang Shuyan Gui Yuanyuan Hu Libo Chen

Diabetic nephropathy (DN) is one of the most common complications associated with type I and II diabetes mellitus. Long noncoding RNAs (lncRNAs) have been implicated in various physiological and pathological processes, and recent evidence has demonstrated that they are involved in the process of the epithelial‑mesenchymal transition (EMT). In the present study, the potential functions of lncRNA...

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