To investigate dipeptide assimilation by the liver, a series of interrelated experiments were performed in rats. Partial hepatectomy prolonged the plasma halflife (min) of Gly-Ala (3.42 f 0.22 uersus 4.90 f 0.35, p < 0.05) but had no significant effect on plasma halflife of Gly-Leu, Gly-Pro, or Gly-Sar. We then investigated the rate of disappearance (pmol*(g liver. h)”) of the above four dipept...

The aim of this study was to try to diagnose malignant liver lesions and hemangiomas by means of vascularisation and perfusion studies. The study was performed in 32 patients with hepatocellular carcinoma (HCC), in 74 with metastatic liver carcinoma (MLC) and in 40 with hemangiomas (H). Color Doppler ultrasonography (DUS) was done with an ATL Ultramark 9 apparatus with convex probe 2.5 MHz usin...

Our aim was to investigate whether dynamic contrast-enhanced ultrasound (DCE-US) can detect early changes in perfusion of colorectal liver metastases after initiation of chemotherapy. Newly diagnosed patients with colorectal cancer with liver metastases were enrolled in this explorative prospective study. Patients were treated with capecitabine or 5-fluorouracil-based chemotherapy with or witho...

Delays between contrast agent (CA) arrival at the site of vascular input function (VIF) sampling and the tissue of interest affect dynamic contrast enhanced (DCE) MRI pharmacokinetic modelling. We investigate effects of altering VIF CA bolus arrival delays on liver DCE MRI perfusion parameters, propose an alternative approach to estimating delays and evaluate reproducibility. Thirteen healthy v...

Due to growing shortage of donor organs, the concept of extracorporeal pig liver perfusion in the treatment of acute liver failure has been rediscovered. Immunomodulation, such as immunoapheresis or inhibition of complement, results in long-term perfusion without exact knowledge of the remaining metabolic graft viability. This study was aimed at the comparison of conventional parameters of graf...

BACKGROUND A protective role for endogenous heme oxygenase (HO) in the initiation of remote liver injury after limb ischemia/reperfusion has been established. This study expands on our previous work by investigating the role of endogenous HO on hepatocellular injury, hepatocyte death (necrotic and apoptotic), and microvascular perfusion at protracted post-reperfusion times. METHODS Remote liv...

conclusions hepatic shock is detected in ill patients, especially those with hemodynamic disorders. it can be prevented by early treatment of underlying disease. there is no definite treatment for hepatic shock and should be managed conservatively. hepatic shock in patients can increase the mortality rate. results different causes can lead to hepatic shock. most of these causes can be prevented...

Isolated organ perfusion of the liver or extremity with tumor necrosis factor (TNF) and melphalan results in regression of bulky tumors in the majority of patients. The efficacy of TNF in this setting is not known, although data suggest that it may exert antitumor effects primarily on tumor-associated neovasculature. We studied the effects of TNF on capillary leak in liver and tumor tissue duri...

The mammalian liver microcirculation seems to be uniquely organized in order to create maximum difference of the biochemical milieu to which the upstream (periportal) and downstream (perivenous) parenchymal cells are exposed. Indeed the existence of a subdivision of hepatocytes in zones of different metabolic function, long predicted by enzyme zonation studies (for a review, see Jungermann & Ka...