we recorded a markedly enhanced immunoglobulin G (IgG) antibody response in the two youngest and most seriously ill test animals. In these, the elimination of L. monocytogenes from the gastrointestinal tract occurred simultaneously with the development of the highest antibody levels at 14 to 15 days postinoculation. In the case of the oldest test animal, a preexisting, persistent IgG antibody r...

Infection by the bacterium Listeria monocytogenes depends on host cell clathrin. To determine whether this requirement is widespread, we analyzed infection models using diverse bacteria. We demonstrated that bacteria that enter cells following binding to cellular receptors (termed "zippering" bacteria) invade in a clathrin-dependent manner. In contrast, bacteria that inject effector proteins in...

Listeria monocytogenes, although an uncommon cause of illness in the general population, is feared principally because of the morbidity and mortality associated with CNS infections. Cardiovascular involvement with L. monocytogenes is very rare, and has been limited to endocarditis. We describe a case of Listeria pericarditis, which occurred in a 60-year-old man with Child-Pugh B cirrhosis who p...

atresia associated with prenatal infection by Listeria monocytogenes. Recent disorganization of extrahepatic bile ducts was shown in a premature infant dying at 3 hours of age of an intrauterine pneumonia associated with an amniotic infection by Listeria monocytogenes. The alimentary canal was heavily infected with Listeria and listerial abscesses were located in the periportal zones of the liv...

microRNAs represent a family of very small non-coding RNAs that control several physiologic and pathologic processes, including host immune response and cancer by antagonizing a number of target mRNAs. There is limited knowledge about cell expression and the regulatory role of microRNAs following bacterial infections. We investigated whether infection with a Gram-positive bacterium leads to alt...

Across the placenta infections include Toxoplasma gondii, Treponema pallidum, Listeria monocytogenes, Plasmodium falciparum (malaria), rubella and cytomegalovirus (CMV). Ascending maternal infection and chorioamnionitis causing fetal infection, usually subsequent to prolonged rupture of membranes. Perinatal infection acquired during birth via the haematogenous or genital route. These include hu...

Neutrophils are the most abundant leukocytes in circulation and provide a primary innate immune defense function against bacterial pathogens before development of a specific immune response. These specialized phagocytes are short lived (12-24 hours) and continuously replenished from bone marrow. We found that if the host is overwhelmed by a high inoculum of Listeria monocytogenes, neutrophils a...

Mice infected with either BCG or Listeria monocytogenes display the same type of cellular response pattern. In both infections there is an intense proliferation of splenic lymphoid cells, a coincident proliferation of differentiated macrophages, and a subsequent production of macrophages with increased metabolic potential. The temporal relations between these events and the onset of host resist...

OBJECTIVE This study aims to investigate the characters of pregnant women and neonates with listeria monocytogenes infections (L. monocytogenes) in Shandong of China. METHOD Pregnant women with premature delivery or prenatal fever were recruited in 2013. Bacterial culture was performed for the umbilical cord blood and placental swab after delivery. The strains isolated were then analyzed for ...

Across the placenta infections include Toxoplasma gondii, Treponema pallidum, Listeria monocytogenes, Plasmodium falciparum (malaria), rubella and cytomegalovirus (CMV). Ascending maternal infection and chorioamnionitis causing fetal infection, usually subsequent to prolonged rupture of membranes. Perinatal infection acquired during birth via the haematogenous or genital route. These include hu...