The objective of the present study was to investigate the clinical and histopathological effects of intravitreal injection of pentoxifylline (PTX) the management of an experimental model of uveitis. Fifty-two rabbits were divided randomly into six intravitreal treated groups as below: 1) Balanced salt solution (BSS), 2) Salmonella typhimurium lipopolysaccharide endotoxin (LPS) + BSS, 3...

Cells of innate immunity, mainly monocytes/macrophages, form a long-term nonspecific immunological memory during the initial encounter with pathogen, so-called trained immunity. Mevalonate pathway metabolites play an important role in formation The aim this investigation was to study effect modulators mevalonate pathway, and zoledronate, on immunity human animal monocytes/ macrophages. Material...

Tamarix aphylla is a commonly grown plant in Saudi Arabia and its therapeutic potential widely recognized. Here, this study, the aim was to explore role of T. leaf extract (TAE) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) mice LPS-stimulated RAW 264.7 cells. The antioxidant anti-inflammatory parameters TAE were performed through vitro assays by measuring H2O2 free radical scaven...

Abstract Objective A preliminary study was conducted to assess the role of Tinospora sinensis extract on liver in mice normal and lipopolysaccharide (LPS)-induced health-compromised conditions. Method Mice (n = 3–5) were randomly assigned into groups I IV for hepatotoxic studies. Group normal, group II given LPS (6 mg/kg, intraperitoneal [ip]), III T. only (1 g/kg/day 21 days), whereas administ...

This study aimed to determine the effects of vitamin C supplementation on antioxidant and inflammatory status cell viability bovine peripheral blood mononuclear cells. Peripheral cells (PBMCs) were isolated from eighteen clinically healthy Japanese Black calves in this study. PBMCs cultured with (vitamin group) without (control stimulated or lipopolysaccharide (LPS). As a result, total capaciti...

Objective(s): Abnormal lung cell death including autophagy and apoptosis is the central feature in acute lung injury (ALI). To identify the cellular mechanisms and the chronology by which different types of lung cell death are activated during lipopolysaccharide (LPS)-induced ALI, we decided to evaluate autophagy (by LC3-II and autophagosome) and apoptosis (by caspase-3) at different time point...

objective(s): gardenia jasminoides ellis (gj, cape jasmine fruit, zhi zi) has been traditionally used for the treatment of infectious hepatitis, aphthous ulcer, and trauma; however, the direct evidence is lacking. materials and methods:we investigated the effect of the gj extract(gj) and gallic acid (ga) on lipopolysaccharide (lps) induced inflammation of bv-2 microglial cells and acute liver i...

septicaemia caused by gram-negative pathogens is a dangerous infection which is associated with high incidence of liver dysfunction. the severe and acute hepatotoxicity is presumably due to massive release of endotoxin into systemic circulation after bacterial killing. the direct toxic effect of endotoxin is probably due to the increased production of reactive oxygen intermediates as o 2 - , pe...