OBJECTIVE To explain the role of oxidative stress in the pathology of celiac disease. DESIGN AND METHODS The activities of antioxidant enzymes and the levels of glutathione and lipid hydroperoxides were measured in the samples of small intestinal biopsies from 39 children with different forms of the disease and in 19 control subjects. RESULTS The activities of analyzed enzymes varied signif...

The present study investigated the antilipoperoixdative and antioxidant effect of morin in normal and streptozotocin-induced diabetic Wistar rats. Diabetes as induced in rats by an intraperitoneal injection of streptozotocin. Morin was orally administered to normal and diabetic rats for a period of 45 days. In diabetic rats, thiobarbituric acid reactive substances and lipid hydroperoxides were ...

The aim of this work was to determine if the inhibition or stimulation of NO synthesis modulates liver damage induced by chronic lead intoxication. Lead nitrate (3.6 mg/kg, per os) was administered one time a day for 30 days to male Wistar rats with low and high resistance to hypoxia treated simultaneously with L-arginine (600 mg/kg, i.p.) or N-nitro-L-arginine (L-NNA, 35 mg/kg, i.p.) 30 min. b...

This study provides the first report of the formation of protein hydroperoxides in cells attacked by reactive oxygen species. U937 cells exposed to peroxyl radicals generated by the thermal decomposition of a water-soluble azo compound gradually accumulated hydroperoxide (-OOH) groups. In an incubation for 22 h, 1.2 mM peroxyl radicals was generated and each cell acquired 1.5x10(8) -OOH groups....

Ferroptosis is a form of programmed cell death associated with iron-dependent lipid peroxidation. Novel ferroptosis inducers and suppressors could be instrumental in developing drugs against neurodegenerative disorders cancer. Prior to embarking on search for inducers/suppressors, this must studied living cells laboratory animals. In addition two cofactors, luciferase (or photoprotein) the parc...

Materials and methods: This study was conducted with rats for a period of 7 days. Group 1 intrarectally received a placebo (0.9% NaCl) and group 2 intrarectally received 2 mL of 5% acetic acid (AA) and the placebo. Group 3 intrarectally received 2 mL of 5% AA and vitamin C (100 mg/kg of body weight) via gastric gavage. Myeloperoxidase (MPO), catalase (CAT), prolidase (PRS), and arylesterase (AR...

Ou et al 1 report that an apolipoprotein A-I (apoA-I) mimetic peptide, D-4F, reduced wall thickness and improved vasoreactivity in the fascialis artery (internal diameter 180 to 240 m) in low-density lipoprotein (LDL) receptor–null mice on a Western diet. If the mice also lacked apoA-I, D-4F improved vasoreactivity but it did not reduce wall thickness. The authors concluded that apoA-I or some ...

In order to find a prophylactic supplementation for individuals who are at risk of exposure to ionizing radiation, we attempted to evaluate the effect of Vitamin E (Vit-E), a biological free radical scavenger, on restoration of hepatic lipid peroxidation (LPO) and lipid profile (LP) changes induced by sublethal g- radiation in BALB/c mice. The concentrations of cholesterol and phospholipid were...

Oxidant generation during regular physical exercise training may influence the adaptive responses that have been shown to confer protection against oxidative stress induced by subsequent acute exercise. To examine this, we randomly assigned 32 males to either a normoxic (n=14) or a hypoxic (n=18) group. During the acute phase, subjects in the hypoxic group performed two maximal cycling tests in...