Linoleic acid was isolated from both the methanol extracts of proso and Japanese millet as a histone deacetylase inhibitor. It showed uncompetitive inhibitory activity toward histone deacetylase (IC(50)=0.51 mM) and potent cytotoxicity toward human leukemia K562 (IC(50)=68 microM) and prostate cancer LNCaP cells (IC(50)=193 microM). Millet containing linoleic acid might have anti-tumor activity.

25 26 27 28 29 30 This study describes a rapid method for identifying bacteria which convert free linoleic acid to conjugated linoleic acid (CLA). The method is based on the spectrophotometric detection of CLA and compares well to the standard GLC method. This method should facilitate the high throughput screening of bacterial isolates for the ability to produce conjugated fatty acids.

In this paper we describe a rapid method for identifying bacteria which convert free linoleic acid to conjugated linoleic acid (CLA). This method is based on spectrophotometric detection of CLA and compares well with the standard gas-liquid chromatography method. This method should facilitate high-throughput screening of bacterial isolates for the ability to produce conjugated fatty acids.

The insulin-independent and combined effects of fatty acids (FA; linoleic and oleic acids) and insulin in modulating lipid accumulation and adipogenesis in 3T3-L1 cells was investigated using a novel protocol avoiding the effects of a complex hormone 'induction' mixture. 3T3-L1 cells were cultured in Dulbecco's modified Eagle's medium (DMEM) plus serum (control) or in DMEM plus either 0.3 mmol/...

two experiments studied the effects of canola or sunflower seed supplementation on conjugated linoleic acid (cla) concentration in milk fat of lactating cows. in each experiment, only eight cows in early lactation were available to assign to one of two treatments in a completely randomized design and were fed individually for 12 wk. experiment 1 compared similar diets with or without the additi...

Abstract:
 Borago officinalis is highly interesting amongst nutritional and medical source relate to its high composition of some useful phytochemical compound. It great plants with bright blue star-shaped flowers present in most world regions usually known as borage. The analysis showed the presence alkaloids, tannins, flavonoids, phenolic acids, essential oil, vitamins others. Borage cul...

Background: For understanding the roles of fatty acids on the induction of acrosome reaction which occurs under association of cholesterol efflux and PKA or PKC pathways in boar spermatozoa, metabolic fate of alone and combined radiolabeled 14C-oleic acid and 3H-linoleic acid incorporated in the sperm was compared, and behavior of cholesterol and effects of PKA and PKC inhibitors upon fatty aci...

the effect of kaolin on fruit and oil of olive cv. `zard’ was evaluated in a commercial orchard in fasacity, fars province. mature olive trees cv. `zard’ were sprayed with 0, 3 and 6% kaolin after 60 days, 60and 90 days and 60, 90, 120 days after full bloom. results showed that kaolin concentration and sprayingtime had not significant effects on physicochemical parameters but they had significa...