Stulak, John M., Luis A. Juncos, John A. Haas, and J. Carlos Romero. Systemic hemodynamics and renal function in hemorrhaged dogs resuscitated with cross-linked hemoglobin. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R28–R33, 2000.—Cross-linked hemoglobin (XL-Hb) infused into dogs increases mean arterial pressure (MAP) but decreases blood flow to the renal (RBF), mesenteric (MBF)...

BACKGROUND AND AIMS We investigated oral delivery of transforming growth factor beta 1 [TGFβ]- and all-trans retinoic acid [ATRA]-loaded microspheres as therapy for gut inflammation in murine models of inflammatory bowel disease [IBD]. METHODS ATRA and TGFβ were separately encapsulated in poly [lactic-co-glycolic] acid or polylactic acid microspheres [respectively]. TGFβ was encapsulated usin...

In the long-term management of ulcerative colitis patients, repeat dosing maybe required. Since 5-ASA is largely absorbed from the upper intestine, selective delivery of drugs into the colon may be regarded as a better method of drug delivery with fewer side effects and a higher efficacy. The aim of this study was to prepare and evaluate a double coated multiparticulate system for 5-ASA deliver...

Functionalized polymeric microspheres based on a modifed polyether ether keetone (PEEK-WC) using immersion precipitation techniques were successfully prepared by doping initial polymeric solutions with DEHPA. The viscosity of the doping solution was measured for determining the optimal value for obtaining reproducible capsules. The modifed microspheres were characterize...

the purpose of this study was to prepare and characterize microspheres loaded by cyclosporine a(cya)-cyclodextrin (cd) complex. to achieve this goal, plga microspheres loaded by cya cd complex were prepared by multiple emulsificationsolvent evaporation methods.morphology, size, encapsulation efficiency and drug release from these microspheres were evaluated. microscopic evaluation of microspher...

Pulsed laser interaction with small metallic and dielectric particles has been receiving attention as a method of drug delivery to many cells. However, most of the particles are attended by many risks, which are mainly dependent upon particle size. Unlike other widely used particles, biodegradable particles have advantages of being broken down and eliminated by innate metabolic processes. In th...

background: radioactive yttrium glass microspheres are used for liver cancer treatment. these yttrium aluminum silicate microspheres are synthesized from yttrium, aluminum and silicone oxides by melting. there are two known processes used to transform irregular shaped glass particles into microspheres, these ‘spheroidization by flame’ and ‘spheroidization by gravitational fall in a tubular furn...

The influence of molecular configuration on the filtration of macromolecules across glomerular capillary walls was examined by comparing fractional clearances of two uncharged polysaccharides of distinctly different molecular configuration in the Munich-Wistar rat. The macromolecules employed were dextran, a slightly branched polymer of glucopyranose, and ficoll, a highly cross-linked copolymer...

Present review article aims to explain use of injectable hydrogels and microspheres derived from natural polysaccharides as drug delivery systems and cell scaffolds. Polysaccharides isolated from natural sources are proved much better than synthetic polymers for making single and composite hydrogels. This paper emphasizes recent developments occurred in use of amphiphilic polysaccharides for bi...