A strategy is presented that allows a causal analysis of co-expressed genes, which may be subject to common regulatory influences. A state-of-the-art promoter analysis for potential transcription factor (TF) binding sites in combination with a knowledge-based analysis of the upstream pathway that control the activity of these TFs is shown to lead to hypothetical master regulators. This strategy...

Research Theme 1. Quantification of trace amount of proteins (Etsuro Ito, Mika Morikawa, Mugiho Kaneda) We are developing the method to detect and quantify very tiny amount of a given protein in a small volume, such as in a single cell. We aim at establishing an enterprise to commercialize protein quantification reagents and kits based on this technique. Using our “enzyme cycling method”, it is...

[1] We present a novel explanation of the physical processes behind one type of cloud and ground-level tornadogenesis within a supercell. We point out that the charge separation naturally found in these large thunderstorms can potentially serve to contract the preexisting angular momentum through the additional process of the electric force. On the basis of this, we present a plausible geometry...

Homomorphic signatures (HS) allows the derivation of the signature of the message-function pair (m, g), where m = g(m1, . . . ,mK), given the signatures of each of the input messages mk signed under the same key. Multi-key HS (M-HS) introduced by Fiore et al. (ASIACRYPT’16) further enhances the utility by allowing evaluation of signatures under different keys. While the unforgeability of existi...

Recent developments in voting theory show that Condorcet profiles embedded in electorates are responsible for conflicts between pairwise voting methods and for reversals of rankings under positional methods whenever candidates are dropped or added. Because of the strong symmetry of the rankings of the candidates within these profiles, it can be argued that Condorcet profiles represent complete ...

The weight increment profiles of 20 low birthweight babies measured during the first two months of extrauterine life were analysed. The babies were weighed daily, and the weight profiles showed minor irregularities when compared with an interpolated linear trend. When increments were plotted at two week intervals a linear increase in weight velocity was seen, but when increments were computed e...

A critical discussion on non-linear steady-state concentration profiles for hydrogen diffusion in elastic metallic membranes, proposed by other authors, is provided based on mathematical analysis and numerical simulation. It is shown that the non-linear distribution is non-existent and the linear form is the only solution for the ideal solid solution phase.  2000 Elsevier Science S.A. All righ...

This paper presents a test of the predictive validity of various classes of QALY models (i.e. linear, power and exponential models). We first estimated TTO utilities for 43 EQ-5D chronic health states and next these states were embedded in nonchronic health profiles. The chronic TTO utilities were then used to predict the responses to TTO questions with nonchronic health profiles. We find that ...

This work presents a method for planning sinusoidal trajectories for an actuated joint, so that the oscillation frequency follows linear profiles, like trapezoidal ones, defined by the user or by a high level planner. The planning method adds a cubic polynomial function for the last segment of the trajectory in order to reach a desired final position of the joint. We apply this planning method ...