The maximum velocities of microsaccades (flicks) are an increasing function of amplitude of movement. Measured velocities fall on the extrapolation of the curve of maximum velocity versus amplitude for voluntary saccades and involuntary corrective saccades. Hence all these movements are produced by a common physiological system, or the characteristics of the movements are determined by a single...

The problem of the form of the 'arctic' curve of the six-vertex model with domain wall boundary conditions in its disordered regime is addressed. It is well-known that in the scaling limit the model exhibits phase-separation, with regions of order and disorder sharply separated by a smooth curve, called the arctic curve. To find this curve, we study a multiple integral representation for the em...

Why is maximal running speed reduced on curved paths? The leading explanation proposes that an increase in lateral ground reaction force necessitates a decrease in peak vertical ground reaction force, assuming that maximum leg extension force is the limiting factor. Yet, no studies have directly measured these forces or tested this critical assumption. We measured maximum sprint velocities and ...

The problem of the form of the 'arctic' curve of the six-vertex model with domain wall boundary conditions in its disordered regime is addressed. It is well-known that in the scaling limit the model exhibits phase-separation, with regions of order and disorder sharply separated by a smooth curve, called the arctic curve. To find this curve, we study a multiple integral representation for the em...

OBJECTIVE The primary objective of this study was to evaluate the safety and tolerability of carboplatin plus pemetrexed for elderly patients (≥75 years) with chemotherapy-naïve advanced non-squamous non-small cell lung cancer. METHODS Patients received escalated doses of carboplatin at an area under the concentration-time curve of 4 (Level 1) or 5 (Level 2) plus pemetrexed (500 mg/m(2)) ever...

We consider a one-dimensional, transient random walk in a random i.i.d. environment. The asymptotic behaviour of such random walk depends to a large extent on a crucial parameter κ > 0 that determines the fluctuations of the process. When 0 < κ < 2, the averaged distributions of the hitting times of the random walk converge to a κ-stable distribution. However, it was shown recently that in this...

We present a model that considers autocrine regulation of tumor growth as a feedback control system. The model is general in that it can accommodate any growth curve which fits the data. We propose an algorithm for quantitation of the open loop gain parameter and we define the autocrine gain parameter; these parameters express the efficiency of the feedback mechanism. The model provides guideli...

Nonlinear kinetic inductance in a high Q superconducting coplanar waveguide microresonator can cause a bifurcation of the resonance curve. Near the critical pumping power and frequency for bifurcation, large parametric gain is observed for signals in the frequency band near resonance. We show experimental results on signal and intermodulation gain which are well described by a theory of the par...

We describe an all CMOS variable gain ampliier (VGA) suitable for use in disk drive read channels. The VGA maintains a 3dB bandwidth greater than 85 MHz throughout its gain range. This ensures good phase linearity for data transfer rates of up to 50Mb/s. The VGA provides a 25dB gain variation along an ideal exponential gain to control voltage curve and 30dB of gain control if ideal exponential ...