Tissue injury (chronic disease) associated with persistent LCM infection is apparently caused by the host immune response to the virus. Employing parabiosis or cell transfer from hyperimmune donors to isologous virus carriers, the tissue injury of chronic disease could be initiated and/or intensified. Furthermore, the transfer of anti-LCM antibody to SWR/J carrier mice results in acute necrotiz...

Due to the complexity of Alzheimer's disease, multiple cellular types need to be targeted simultaneously in order for a given therapy to demonstrate any major effectiveness. Ultrasound-sensitive coated microbubbles (in a targeted lipid nanoemulsion) are available. Versatile small molecule drug(s) targeting multiple pathways of Alzheimer's disease pathogenesis are known. By incorporating such dr...

Lymphocytic choriomeninigitis (LCM) virus defective interfering (DI) particles form foci of protected cells in a monolayer under an agarose-containing overlay medium. Foci originate from one cell dually infected with at least 1 interference focus-forming unit and infectious virus. As a result, an interfering factor is produced and released which interacts with neighboring cells, thereby protect...

The ability to reliably analyze cellular and molecular profiles of normal or diseased tissues is frequently complicated by the inherent heterogeneous nature of tissues. Laser Capture Microdissection (LCM) is an innovative technique that allows the isolation and enrichment of pure subpopulations of cells from tissues under direct microscopic examination. Material obtained by LCM can be used for ...

ÐIn many scientific applications, dynamic array redistribution is usually required to enhance the performance of an algorithm. In this paper, we present a generalized basic-cycle calculation (GBCC) method to efficiently perform a BLOCK-CYCLIC(s) over P processors to BLOCK-CYCLIC(t) over Q processors array redistribution. In the GBCC method, a processor first computes the source/destination proc...

This paper discusses the optimal H2 and H∞ control problems for networked systems with limited communication constraint. The limited communication constraint in control networks is taken into consideration in controller design by employing the notion of communication sequence. Our objective is to find an optimal communication sequence and the corresponding optimal controller for the given plant...

Lacosamide (LCM) is a novel agent that has been developed as an antiepileptic drug. In vitro studies suggest that LCM modulates voltage-gated sodium channels by enhancing their slow inactivation. In addition, LCM seems to interact with collapsin-response mediator protein 2 and thus may mediate neuronal plasticity. LCM has an elimination half-life of 13 hours, no relevant protein binding, and do...

Laser capture microdissection (LCM) offers a reliable cell population enrichment tool and has been successfully coupled to MS analysis. Despite this, most proteomic studies employ whole tissue lysate (WTL) analysis in the discovery of disease biomarkers and in profiling analyses. Furthermore, the influence of tissue heterogeneity in WTL analysis, nor its impact in biomarker discovery studies ha...

This paper presents a new hybrid method for solving constraint optimization problems in anytime contexts. Discrete optimization problems are modelled as Valued CSP. Our method (VNS/LDS+CP) combines a Variable Neighborhood Search and Limited Discrepancy Search with Constraint Propagation to efficiently guide the search. Experiments on the CELAR benchmarks demonstrate significant improvements ove...