The Shaker B K(+) conductance (G(K)) collapses (in a reversible manner) if the membrane is depolarized and then repolarized in, 0 K(+), Na(+)-containing solutions (Gómez-Lagunas, F. 1997. J. Physiol. 499:3-15; Gómez-Lagunas, F. 1999. Biophys. J. 77:2988-2998). In this work, the role of Na(+) ions in the collapse of G(K) in 0-K(+) solutions, and in the behavior of the channels in low K(+) was st...

The activity of neurons is critically dependent upon the suite of voltage-dependent ion channels expressed in their membranes. In particular, voltage-gated K+ channels are extremely diverse in their function, contributing to the regulation of distinct aspects of neuronal activity by shaping the voltage responses. In this study the role of K+ channels in neural coding is investigated in Drosophi...

Introduction and Objectives Transition metal concentrations in the central nervous system (CNS) are implicated in neurodegenerative diseases such as Alzheimer's, Parkinson's and Multiple Sclerosis. A common symptom of these diseases is demyelination, which is the degradation of the myelin sheath that encapsulates the neurons in vertebrates. A dysmyelinating rodent model (Long Evans Shaker (LES)...

embolectomy has long been the gold standard for treating limbs acutely threatened by arterial occlusion. delayed embolectomy has not been investigated adequately due to the belief that accompanying mortality and morbidity render the case futile. following our previous experience with late arterial repair for leg or knee salvage i we applied the same principle to limbs threatened with prolonged ...

This study aims to determine the concentration of methanol solvent, temperature, and time shaker in best extraction. It can produce antioxidant activity peel yellow passion fruit (Passiflora edulis Sims f. flavicarpa Deg) using DPPH method. The maceration process is carried out solvents. filtrate concentrated with a rotary evaporator until extract obtained. Variations concentrations include 60,...

This article presents a novel methodology conducted under controlled laboratory conditions to assess the dynamic behavior of components railway tracks by applying an unbalanced mass excitation force. The for obtaining accurate measurements, which uses different parameters, is based on device, and from these data, transmissibility mass-elastomer system estimated. For assessment behavior, sine sw...