Human kallikrein 6 (hK6), also known as zyme/protease M/neurosin), is expressed in many normal glandular tissues. The aim of this study was to determine whether hK6 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), using an immunohistochemical method. Pleomorphic adenomas (PA), adenoid cystic carcinomas, polymorphous low-grade adenocarcinomas, acinic ...

PURPOSE Lymphocytic infiltration of tumors predicts improved survival in patients with breast cancer. Previous studies have suggested that this survival benefit is confined predominantly to the basal-like subtype. Immune infiltration in ovarian tumors is also associated with improved prognosis. Currently, it is unclear what aspects of the immune response mediate this improved outcome. EXPERIM...

Immunogenic non-replicative recombinant modified vaccinia virus Ankara (rMVA) has been developed to turn "cold" tumors into "hot" tumors. MVAΔE5R-hFlt3L-mOX40L is our first-generation rMVA by deleting a cGAS (cyclic GMP-AMP synthase) inhibitor encoded the E5R gene and inserting human Flt3L (a growth factor for dendritic cells) murine OX40L co-stimulatory molecule T cells). In this study, we use...

Primary Adenoid Cystic Carcinoma of Breast (bACC) is an extremely rare salivary gland like tumor accounting for less than 0.1% all breast tumors with excellent prognosis. These are generally triple negative. There limited data on optimal treatment and management.

Natural killer (NK) cells are effector cells of the innate immune system that exert direct cytotoxic functions. Ubiquitously-expressed toll-like receptors (TLRs) have been recognized as one of the major components promoting dendritic cell (DC) maturation, which may induce polarized immune responses beneficial to cancer immunotherapy. TLR-activated NK cells and DCs are prerequisite for robust ac...

cytomegalovirus (cmv) is a widespread pathogen that is found in milk, saliva, urine, cervical secretions, and semen fluid. it is supposed that cmv is a risk factor for breast cancer. the aim of this study was to determine the frequency of cmv among benign and malignant breast tumors. paraffin embedded breast carcinoma (n=24) and fibroadenoma (n=24) samples were collected from toos and firoozgar...

purpose: to report an extremely rare presentation of isolated orbital xanthogranuloma with no systemic disease, nor dermatologic manifestation. case report: the patient was a 45-year-old man complaining of a mass lesion in the superior and inferior eyelids of his right eye; the lesions had been enlarging slowly and painlessly since 5 years before. other examinations (including skin, heart, etc....

abstract objective tumors of the central nervous system constitute the largest group of solid neoplasms in children and are second only to leukemia in their overall frequency during childhood. the main purpose of the present study is to determine the incidence, age, sex, location and histological diagnosis of cns tumors in children, less than 15 years of age, in the mofid children's hospital, i...

intracranial hemangiopericytomas (hpc) are rare vascular tumors. they account for 0.4% of primary central nervous system tumors. hpc is more commonly located supratentorially and tends to occur in a younger age group, with average age at presentation of 38–42 years. the tumor was found throughout the entire cns, usually superficially and closely related to the meninges. moreover, they have a st...

Epithelial-mesenchymal transition (EMT) is important for tumor metastasis. Detection of EMT protein expression and observation of morphological changes are commonly used to identify EMT. Diffusion-weighted magnetic resonance imaging (DW-MRI) and measuring apparent diffusion coefficient (ADC) values are noninvasive techniques for characterizing tumor microenvironments. We investigated the differ...