Possible pathogenic mechanisms of sporadic inclusion-body myositis (sIBM) include abnormal production and accumulation of amyloid beta (A beta), muscle aging, and increased oxidative stress. Insulin-like growth factor I (IGF-I), an endocrine and autocrine/paracrine trophic factor, provides resistance against A beta toxicity and oxidative stress in vitro and promotes cell survival. In this study...

Inclusion body myositis (IBM), the most common age-related muscle disease in the elderly population, is an incurable disorder leading to severe disability. Sporadic IBM has an unknown etiology, although affected muscle fibers are characterized by many of the pathobiochemical alterations traditionally associated with neurodegenerative brain disorders such as Alzheimer's disease. Accumulation of ...

Iterative methods of Laguerre’s type for the simultaneous inclusion of all zeros of a polynomial are proposed. Using Newton’s and Halley’s corrections, the order of convergence of the basic method is increased from 4 to 5 and 6, respectively. Further improvements are achieved by the Gauss-Seidel approach. Using the concept of the R-order of convergence of mutually dependent sequences, we presen...

By applying the concept of partially relaxed -strong monotonicity of set-valued mappings due to author and the auxiliary variational inequality technique, some new predictor–corrector iterative algorithms for solving generalized mixed quasi-variational-like inclusions are suggested and analyzed. The convergence of the algorithms only need the continuity and the partially relaxed -stronglymonoto...

in this article we consider the averaging method for differential inclusions with fuzzy right-hand side for the case when the limit of a method of an average does not exist.

In this paper, using Lipschitz continuity of general (H, η)-monotone operators, a type of implicit variational-like inclusion problems in uniformly smooth Banach spaces are solved.

A new paradigm for economic growth is financial inclusion, particularly in emerging markets like India. It serves as a crucial indicator of nation's and economy's overall development. The ability to navigate the world, make wise decisions, reduce likelihood being deceived about money all result from having literacy abilities. purpose this paper explore concept current scenario Financial Inclusi...

BACKGROUND AND OBJECTIVES MYH9-related disorders are autosomal dominant hereditary macrothrombocytopenias caused by mutations in the MYH9 gene. This gene encodes the non-muscular myosin heavy chain type II A (MHCIIA). Among these disorders, May-Hegglin anomaly (MHA), Sebastian syndrome (SS), and Fechtner syndrome (FS) are associated with different types of ribosome inclusions in granulocytes. F...

BACKGROUND The molecular mechanics of inclusion body formation is still far from being completely understood, specially regarding the occurrence of properly folded, protein species that exhibit natural biological activities. We have here comparatively explored thermally promoted, in vivo protein aggregation and the formation of bacterial inclusion bodies, from both structural and functional sid...