BACKGROUND Pain of circumcision is only partially relieved by single modalities, such as penile nerve block, lidocaine-prilocaine cream, and sucrose pacifiers. OBJECTIVE To assess the effectiveness of a combination of interventions on the pain response of infants undergoing circumcision. METHODS Cohort study. Group 1 included infants circumcised using the Mogen clamp and combined analgesics...

background: opiate is used in patient-controlled intravenous analgesia pumps (pcia) for controlling pain in post-surgical patients.other drugs are remarkably added to opioid pumps to enhance quality, lengthen analgesia, and reduce side effects. lidocaine, a local anesthetic which inhibits sodium channels, has anesthetic and analgesic effects when injected locally or intravenously. the objective...

Lidocaine is a commonly used local anaesthetic that, besides blocking voltage-dependent Na(+) channels, has multiple inhibitory effects on muscle-type nicotinic acetylcholine (ACh) receptors (nAChRs). In the present study, we have investigated the effects of lidocaine on ACh-elicited currents (IAChs) from cultured mouse superior cervical ganglion (SCG) neurons, which mainly express heteromeric ...

abstract aims: spices are sources of many bioactive compounds that can improve the taste of food as well as affecting the digestion and metabolism. along with that, they may also contain some substances as heavy metals, which have harmful effects on the body. the aim of present study was to assess the potential health risk of cr, cu, fe and zn contents of cardamom, curry powder and turmeric in ...

The diastolic pressure-volume curve shifts upward during demand ischemia, most likely because of changes in Ca2+ dynamics within the sarcomere. It is possible that agents that affect Na+/Ca2+exchange, such as lidocaine, a class 1b-type Na+-channel blocker that decreases intracellular Na+, could affect the diastolic pressure-volume relationship because of indirect effects on intracellular Ca2+. ...

TOPIC: Cardiovascular Disease TYPE: Medical Student/Resident Case Reports INTRODUCTION: The frequency of new onset left bundle branch block (LBBB) during anaesthesia and surgery is rare. most common causes for LBBB are structural heart diseases, acute myocardial infarction, dilated cardiomyopathy, failure, exercise-induced LBBB[1]. We present a rare case Lidocaine-induced Intermittent Left Bund...

BACKGROUND This study aimed to evaluate the effects of lidocaine treatment on cognitive impairment in aged patients undergoing spine surgery and to explore the underlying mechanism. MATERIAL/METHODS Patients were randomly divided into 2 treatment groups: (1) saline (control) and (2) lidocaine. After induction of anesthesia, the lidocaine group received lidocaine as a bolus of 1 mg/kg over 5 m...

STUDY OBJECTIVE The study aims to evaluate the efficacy and safety of intranasal lidocaine administration for migraine treatment. METHODS This single-center, double-blind, randomized, controlled trial was conducted in a tertiary care emergency department. Included patients met the migraine criteria of the International Headache Society. Patients were randomized to intranasal lidocaine or sali...

Topical analgesics can play an important role in the therapeutic armamentarium for pain management. The mechanism of action of topical analgesics is largely within the peripheral nervous system. However, recent clinical investigations suggest that the effect of topical analgesics on peripheral processing of pain transmission may lead to the dampening of central pain mechanisms as well. Thus, in...