OBJECTIVES To test the efficacy of a new intravesical therapeutic solution in relieving urgency/frequency and pain in interstitial cystitis (IC). METHODS A solution of 40,000 U heparin, 8 mL 1% lidocaine (80 mg; group 1) or 2% lidocaine (160 mg; group 2), and 3 mL 8.4% sodium bicarbonate was administered intravesically in patients with newly diagnosed IC with significant frequency, urgency, a...

ObjectiveTo evaluate the total toxic dose of lidocaine and serum lidocaine concentrations resulting in clinical signs of toxicity in chickens. DesignExperimental study AnimalsEight healthy, female, 55-week-old chickens (Lohman breed) weighing 1.45 ± 0.17 kg (mean ± SD) ProcedureA loading dose of 2% lidocaine (4 mg/kg) was administered IV, followed by a constant-rate infusion at a dose of 8 mg/k...

introduction: considering the anti-inflammatory role of intravenous (iv) lidocaine, its analgesic properties, and its ability to reduce the need for opioids during and after surgery, in this study we decided to evaluate the effect of iv lidocaine infusion on levels of inflammatory factors based on neutrophil to lymphocyte ratio (nlr) in breast cancer surgery candidates. methods: the present stu...

BACKGROUND The purposes of the present investigation were 1) to track the incidence of primary ventricular fibrillation (VF) in the control and lidocaine-treated groups in the randomized control trials (RCTs) of lidocaine prophylaxis against primary VF in acute myocardial infarction, with particular emphasis on the time frame of the randomized trial, and 2) to estimate the number of patients wh...

BACKGROUND Lidocaine, a local anesthetic, can be neurotoxic. However, the cellular mechanisms of its neurotoxicity at concentrations encountered during spinal anesthesia remain unclear. METHODS The authors examined the mechanisms of lidocaine neurotoxicity in the ND7 cell line derived from rat dorsal root ganglion. Individual neurons were assayed by flow cytometry or microscopy using fluoresc...

The DentiPatch lidocaine transoral delivery system (Noven Pharmaceuticals) is indicated for mild topical anesthesia of mucosal membranes in the mouth. The DentiPatch is a mucoadhesive patch containing 46.1 mg of lidocaine (20% concentration). Current studies in adults report that DentiPatch application produces very low plasma concentrations of lidocaine. However, it is not known what plasma le...

b o m o B e c t e bstract his randomized crossover double-blind trial compared he efficacy of buccal infiltration with 4% articaine and % lidocaine (both with 1:100,000 epinephrine) in ecuring mandibular first molar pulp anesthesia. Injecions were given at least 1 week apart in 31 healthy dult volunteers. Electronic pulp testing was underaken at baseline and at 2 minute intervals until 30 inute...

We demonstrated that upregulation of both gene expression of endoplasmic reticulum (ER) stress chaperones (BiP, calnexin, calreticulin, and PDI) and ER stress sensors (ATF6, IRE1 and PERK) was induced by lidocaine, a local anesthetic, in PC12 cells. In addition to gene regulation, lidocaine also induced typical ER stress phenomena such as ART6 proteolytic cleavage, eIF2 alpha phosphorylation, a...

Alparslan Turan, MDठBACKGROUND: In this study, we evaluated the effect of paracetamol on sensory and motor block onset time, tourniquet pain, and postoperative analgesia, when added to lidocaine in IV regional anesthesia (IVRA). METHODS: Sixty patients undergoing hand surgery were randomly and blindly divided into three groups. All groups received IVRA lidocaine (3 mg/kg) diluted with saline ...