background: studies demonstrated controversial results on subclinical hypothyroidism (sch) regarding lipid profile alteration with or without levothyroxine treatment. the purpose of this study is to investigate the effects of levothyroxine on serum lipids in sch. materials and methods: one hundred patients with sch referred to taleghani hospital in kermanshah were recruited and randomly assigne...

background: rise in serum homocysteine level may be associated with higher prevalence of cardiovascular diseases in hypothyroidism. levothyroxine can partly diminish serum homocysteine level. folic acid participates in homocysteine metabolic cycle in the human body. the effect of concomitant administration of folic acid and levothyroxine on serum homocysteine level was evaluated in the present ...

Abstract Introduction Rifampin has a wide range of drug interactions through increased hepatic microsomal enzyme activity. We are reporting case patient with post-surgical hypothyroidism on stable thyroid hormone replacement therapy who required significantly higher doses levothyroxine after starting rifampin. Case Report Patient is 78-year-old woman history Papillary Thyroid Cancer (PTC) in re...

After reading the interesting case report by Llamas-Velasco et al.,1 we would like to add a comment. The authors described a case of acquired generalized lipodystrophy (AGL) with muscle involvement. The index patient with AGL had normal muscle strength and biopsy report. The evidence of muscle involvement were the presence of high creatine kinase levels and a myopathic pattern on electromyograp...

There are many reports that show different thyroid abnormalities in schizophrenia without clear establishment of their role in etiology and treatment outcome of schizophrenia. Among these reports, there are only a few that consider a role for thyroid hormones as augmenting agents in the treatment with antipsychotic drugs. This case report outlines symptom subsidence of a patient with clozapine ...

On June 24, 2004, the U.S. Food and Drug Administration (FDA) rejected a citizen petition filed in August 2003 regarding bioequivalence of levothyroxine sodium products and approved first-time generic levothyroixine sodium for the treatment of hypothyroidism. The American Thyroid Association (ATA), The Endocrine Society (TES), and the American Association of Clinical Endocrinologists (AACE), re...

Introduction Recent prescribing policies in England and Wales have imposed significant restrictions on liothyronine general practice driven by the prohibitive costs uncertain benefits of management hypothyroidism. However, impact these usage is still unclear. Methods Data were downloaded from NHS monthly General Practice Prescribing Comparative Analysis System for Audit (CASPA) 2011–2020. Trend...

Known effects of levothyroxine and folic acid on serum homocysteine level

The consequences of inadequate thyroid hormone availability to the brain and treatment effects of levothyroxine on cognitive function are still poorly understood. This study prospectively assessed the effects of thyroid replacement therapy on cognitive function in patients suffering from biochemical evidenced, untreated hypothyroidism. Significant effects between the untreated hypothyroid group...

A man diagnosed with alcoholic liver cirrhosis complained of abdominal distention due to massive ascites. The ascites did not resolve with diuretic agents. The serum-ascites albumin gradient value of 1.9 g/dL and the total protein level in the ascites of 3.1 g/dL indicated the ascites to have been caused by portal hypertension. Hypothyroidism was detected, and the patient received supplementati...