نتایج جستجو برای: leucovorin
تعداد نتایج: 2615 فیلتر نتایج به سال:
In RCT both tegafur + calcium folinate and capecitabine had a statistically signi cant advantage over 5- uorouracil + calcium folinate: the full and partial objective tumor response was achieved in more patients (table 1). There was no statistically signi cant difference between oral tegafur, both in monotherapy or in combination with calcium folinate, and capecitabine for advanced CRC treat...
In recent years methotrexate has been used increasingly in combination chemo-therapeutic regimens for the treatment of aggressive non-Hodgkin's lymphoma. I Its principal toxic effects are bone marrow suppression, gastrointestinal mucositis, hepatitis, renal impairment, and erythematous rashes. The Stevens-Johnson syndrome has been reported previously in two children receiving high-dose methotre...
PURPOSE The Gruppo Oncologico Nord Ovest (GONO) conducted a phase III study comparing fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI [irinotecan 165 mg/m2 day 1, oxaliplatin 85 mg/m2 day 1, leucovorin 200 mg/m2 day 1, fluorouracil 3,200 mg/m2 48-hour continuous infusion starting on day 1, every 2 weeks]) with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI). MET...
PURPOSE This phase I study was designed to determine the optimally tolerated regimen (OTR), safety, and clinical activity of lapatinib in combination with FOLFOX4 [oxaliplatin/leucovorin/5-fluorouracil (5-FU)] in patients with solid tumors. Furthermore, the pharmacokinetics of lapatinib, oxaliplatin, and 5-FU when given alone and in combination were evaluated. EXPERIMENTAL DESIGN This study w...
Advanced or metastatic gastric cancer, which is one of the most common malignancies in Korea, is difficult to cure by surgery alone and generally requires combination chemotherapy. Paclitaxel is active against gastric cancer and when combined with 5-fluorouracil/leucovorin and/or cisplatin is effective in the treatment of gastric cancer. We attempted to determine the effect and safety with the ...
: High-dose methotrexate (HDMTX), defined as a dose higher than 500 mg/m2, is used to treat a range of adult and childhood cancers. Although HDMTX is safely administered to most patients, it can cause significant toxicity, including acute kidney injury (AKI) in 2%-12% of patients. Nephrotoxicity results from crystallization of methotrexate in the renal tubular lumen, leading to tubular toxicity...
PURPOSE The purpose of this study was to evaluate efficacy and toxicity of irinotecan, leucovorin and 5-fluorouracil (FOLFIRI) as second-line treatment after failure of oxaliplatin, leucovorin and 5-fluorouracil (FOLFOX) for advanced gastric cancer. MATERIALS AND METHODS Patients who received modified FOLFOX-4 as first-line treatment and then received sequential modified FOLFIRI for disease p...
PURPOSE Irinotecan, in combination with leucovorin/5-fluorouracil (FU) or with cisplatin, is known to be active for treating advanced gastric cancer (AGC). This pilot study evaluated a novel three-drug combination of irinotecan, leucovorin/FU and cisplatin as a first-line treatment of AGC. The primary endpoint was to assess the feasibility in anticipation of conducting a larger phase II study. ...
1. The European corn borer larva has been shown to require a dietary source of one or more unidentified factors contained in corn leaves, grass juice concentrate, and certain other plant materials. The required factor or factors has been termed the corn leaf factor. 2. The corn leaf factor does not appear to be identical with any of the known B vitamins, or with ascorbic acid, sodium nucleate, ...
Since cancer is incurable in many patients, palliation of symptoms and quality-of-life issues are important aspects of therapy. Uracil and tegafur (UFT) plus calcium folinate are the components of the oral agent known as Orzel, which offers activity comparable to intravenously administered 5-fluorouracil (5-FU) combined with calcium folinate. Paclitaxel (Taxol), administered intravenously on a ...
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