Perinatal lethal osteogenesis imperfecta is the result of heterozygous mutations of the COL1A1 and COL1A2 genes that encode the alpha 1(I) and alpha 2(I) chains of type I collagen, respectively. Point mutations resulting in the substitution of Gly residues in Gly-X-Y amino acid triplets of the triple helical domain of the alpha 1(I) or alpha 2(I) chains are the most frequent mutations. They int...

BATF firearms traces are a tool for prosecution of individual crimes, with potential benefits in using the tracing data for law enforcement. There are, however, severe limitations on the utility of those data for criminological analysis and public policymaking aimed at reducing homicides, including the minimal number of trace attempts and successes, the rules for excluding guns and efforts to t...

Lethal mutagenesis, the killing of a microbial pathogen with a chemical mutagen, is a potential broad-spectrum antiviral treatment. It operates by raising the genomic mutation rate to the point that the deleterious load causes the population to decline. Its use has been limited to RNA viruses because of their high intrinsic mutation rates. Microbes with DNA genomes, which include many viruses a...

Muin J. Khoury, Julian Little, Julian Higgins, John P. A. Ioannidis, Marta Gwinn We applaud PLoS editors for their commitment to publishing high-quality systematic reviews (SRs) [1]. Moher et al. [2] clearly documented the inconsistent quality of reporting of SRs. With more than 2,500 SRs published every year, low-quality or outdated reviews may mislead researchers, providers, and policy makers...

of R. stolonifer, even after a radiation exposure (LDgg) SOMMER, N. F. (University of California, Davis), MIN capable of inactivating the colony-forming ability of the T. CREASY, E. C. MAxIE, AND R. J. RoMANI. Production fungus. This was considered evidence that maceration was Of pectolytic enzymes by Rhizopus stolonifer continuing, even after most fungal cells supposedly had spores after "leth...