Leishmaniasis is a neglected tropical disease caused by a protozoan parasite of the genus Leishmania. Visceral leishmaniasis is the most severe type and is transmitted by the phlebotomine sandflies of genera Lutzomyia (New World) or Phlebotomus (Old World) to human and other vertebrates. Leishmaniasis is widespread in developing countries with current mortality rate of 50 thousand deaths per ye...

AIM There are six main types of granulomas in dermatopathology. The aim is to present and describe a seventh pattern of granuloma that we came across while studying biopsies of cutaneous leishmaniasis. MATERIALS AND METHODS We investigated 17 cases of cutaneous leishmaniasis. A granulomatous response was identified in 14 of them. The features that were common to all of them were noted. These ...

UNLABELLED Leishmaniasis infection may involve destruction of nasal tissues resulting in lacrimal drainage system alteration. PURPOSE To evaluate the frequency of lacrimal excretory system sequelae in patients treated for leishmaniasis. METHODS Forty-five leishmaniasis-treated patients (90 nasolacrimal ducts) were submitted to lacrimal excretory system evaluation. All were evaluated by Jone...

Interleukin 17 (IL-17) plays a critical role in inflammation and autoimmunity. Very little is known about IL-17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL-17 than do lymphocytes obtained from uninfected control subjects (P<.01). There was a tendency for tissue obtained from patie...

Leishmaniasis is a protozoan parasitic disease endemic to the tropical and subtropical regions of the world, with three major clinical forms, self-healing cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), and visceral leishmaniasis (VL). Drug treatments are expensive and often result in the development of drug resistance. No vaccine is available against leishmaniasis. Subunit Lei...

Chagas disease and leishmaniasis are vector-borne infectious diseases affecting both humans animals. These neglected tropical can be fatal if not treated. Hundreds to thousands of new disease...

Forty-one naturally infected dogs with visceral leishmaniasis from an urban area of Corumbá (Mato Grosso do Sul-BRAZIL) were studied and three types of lung involvement due to visceral leishmaniasis were characterized; a cellular, a cellular-fibrotic and a fibrotic type. These types seem to represent a sequential evolutive proce'as. Visceral leishmaniasis frequently causes an interstitial pneu ...

Leishmaniases, caused by the intracellular protozoan Leishmania infantum, are an endemic zoonosis in the Mediterranean basin. Dogs are considered the major host for these parasites, and the main reservoir for human visceral infection. Parasites are transmitted by the bite of phlebotomine sand flies, being Phlebotomus perniciosus and P. ariasi the proven vectors in Portugal. The global climate c...

The cytokine profile produced by peripheral blood mononuclear cells (PBMC) in response to leishmania antigens and the ability of interleukin-10 (IL-10) and transforming growth factor beta (TGF-beta) to modulate the immune response were evaluated in 21 mucosal leishmaniasis patients. Patients with mucosal disease exhibited increased gamma interferon (IFN-gamma) and tumor necrosis factor alpha (T...

To the Editor: The report of a human cutaneous leishmaniasis case acquired in Clairvaux-les-lacs (1) led us to carry out an investigation with the veterinary clinics in Jura Department, France. Clairvaux-leslacs is a lakeside resort located in Jura, one of the areas in France with the coldest average temperatures, and is clearly located outside the usual leishmaniasis-endemic area. At least 31 ...