نتایج جستجو برای: leishmania tarentolae

تعداد نتایج: 13657  

Journal: :Journal of virological methods 2016
Kerstin Fischer Vinicius Pinho dos Reis Stefan Finke Lucie Sauerhering Eileen Stroh Axel Karger Andrea Maisner Martin H Groschup Sandra Diederich Anne Balkema-Buschmann

Hendra virus (HeV) is an emerging zoonotic paramyxovirus within the genus Henipavirus that has caused severe morbidity and mortality in humans and horses in Australia since 1994. HeV infection of host cells is mediated by the membrane bound attachment (G) and fusion (F) glycoproteins, that are essential for receptor binding and fusion of viral and cellular membranes. The eukaryotic unicellular ...

2015
Mehdi Shahbazi Farnaz Zahedifard Tahereh Taheri Yasaman Taslimi Shahram Jamshidi Sadegh Shirian Niousha Mahdavi Mehdi Hassankhani Yahya Daneshbod Sayyed Hamid Zarkesh-Esfahani Barbara Papadopoulou Sima Rafati Kevin K.A. Tetteh

Canine Visceral Leishmaniasis (CVL) is a major veterinary and public health problem caused by Leishmania infantum (L. infantum) in many endemic countries. It is a severe chronic disease with generalized parasite spread to the reticuloendothelial system, such as spleen, liver and bone marrow and is often fatal when left untreated. Control of VL in dogs would dramatically decrease infection press...

Journal: :RNA 2003
Ruslan Aphasizhev Inna Aphasizheva Robert E Nelson Larry Simpson

A stable 100-kD complex from mitochondria of Leishmania tarentolae containing two RNA-binding proteins, Ltp26 and Ltp28, was identified by cross-linking to unpaired 4-thiouridine nucleotides in a partially duplex RNA substrate. The genes were cloned and expressed and the complex was reconstituted from recombinant proteins in the absence of RNA or additional factors. The Ltp26 and Ltp28 proteins...

Journal: :RNA 2000
M A Rubio X Liu H Yuzawa J D Alfonzo L Simpson

All mitochondrial tRNAs in kinetoplastid protozoa are encoded in the nucleus and imported from the cytosol. Incubation of two in vitro-transcribed tRNAs, tRNA(Ile)(UAU) and tRNA(Gln)(CUG), with isolated mitochondria from Leishmania tarentolae, in the absence of any added cytosolic fraction, resulted in a protease-sensitive, ATP-dependent importation, as measured by nuclease protection. Evidence...

Journal: :The EMBO journal 1999
C Kündig A Haimeur D Légaré B Papadopoulou M Ouellette

Functional cloning led to the isolation of a novel methotrexate (MTX) resistance gene in the protozoan parasite Leishmania. The gene corresponds to orfG, an open reading frame (ORF) of the LD1/CD1 genomic locus that is frequently amplified in several Leishmania stocks. A functional ORF G-green fluorescence protein fusion was localized to the plasma membrane. Transport studies indicated that ORF...

2016
Katarzyna Grzyb Anna Czarnota Agnieszka Brzozowska Anna Cieślik Łukasz Rąbalski Jolanta Tyborowska Krystyna Bieńkowska-Szewczyk

Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are the main inducers of a cross-neutralizing antibody response which plays an important role in the early phase of viral infection. Correctly folded and immunologically active E1E2 complex can be expressed in mammalian cells, though the production process might still prove restrictive, even if the immunological response of a vaccine cand...

2015
Paul-Andre Genest Loren Baugh Alex Taipale Wanqi Zhao Sabrina Jan Henri G.A.M. van Luenen Jonas Korlach Tyson Clark Khai Luong Matthew Boitano Steve Turner Peter J. Myler Piet Borst

Base J (β-D-glucosyl-hydroxymethyluracil) replaces 1% of T in the Leishmania genome and is only found in telomeric repeats (99%) and in regions where transcription starts and stops. This highly restricted distribution must be co-determined by the thymidine hydroxylases (JBP1 and JBP2) that catalyze the initial step in J synthesis. To determine the DNA sequences recognized by JBP1/2, we used SMR...

2014
RUSSELL E. COLEMAN LISA P. HOCHBERG KATHERINE I. SWANSON JOHN S. LEE JAMES C. MCAVIN JOHN K. MOULTON DAVID O. EDDINGTON JENNIFER L. GROEBNER MONICA L. O’GUINN JOHN L. PUTNAM

Sandßies collectedbetweenApril 2003 andNovember 2004 atTallilAirBase, Iraq,were evaluated for the presence of Leishmania parasites using a combination of a real-time Leishmaniageneric polymerase chain reaction (PCR) assay and sequencing of a 360-bp fragment of the glucose6-phosphate-isomerase (GPI)gene.A total of 2,505pools containing 26,574 sandßieswere testedusing the real-time PCR assay.Leis...

2017
Jade Katinas Rachel Epplin Christopher Hamaker Marjorie A. Jones

Introduction Leishmaniasis is an endemic disease caused by the protozoan parasite Leishmania. Current treatments for the parasite are limited by cost, availability and drug resistance as the occurrence of leishmaniasis continues to be more prevalent. Sulfonamides are a class of compounds with medicinal properties which have been used to treat bacterial and parasitic disease via various pathways...

Journal: :Parasitology 2004
G E Luyo-Acero H Uezato M Oshiro K Takei K Kariya K Katakura E Gomez-Landires Y Hashiguchi S Nonaka

The Cytochrome b (Cyt b) gene has proved to be useful for identification and classification of many mammals and plants. In order to evaluate the utility of this gene for discrimination of Leishmania parasites as well as for exploring their phylogenetic relationships, we determined the nucleotide sequences of the Cyt b gene from 13 human-infecting Leishmania species (14 strains) from the New and...

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