BACKGROUND Glycodelin, a glycoprotein, is present in both blood plasma and uterine flushings. It has been implicated in the process of implantation and angiogenesis. During the secretory phase, progesterone secretion is related to glycodelin production. METHODS AND RESULTS We obtained uterine flushings, prospectively, from 47 infertile patients during the proliferative phase. Patients were re...

CONTEXT Development of optimal medicinal treatments of uterine leiomyomas represents a significant challenge. 2-Methoxyestradiol (2ME) is an endogenous estrogen metabolite formed by sequential action of CYP450s and catechol-O-methyltransferase (COMT). Our previous study demonstrated that 2ME is a potent antiproliferative, proapoptotic, antiangiogenic, and collagen synthesis inhibitor in human l...

Objectives: To study the histomorphological features of variants of leiomyomas of myometrium in our institution from hysterectomy and myomectomy specimens. Methods: In this prospective study, 1,845 hysterectomy and myomectomy specimens collected over a period of two years were studied. A detailed gross and microscopic examination of tumors of myometrium were made after fixing and staining the s...

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominantly inherited syndrome. MEN1 is characterized by the presence of functioning and nonfunctioning tumors or hyperplasia of the pituitary gland, parathyroid glands, and pancreatic islet cells. In addition, MEN1 carriers can have adrenal or thyroid tumors and non-endocrine tumors, such as lipomas, angiofibromas, and leiomyomas. Altho...

Broad ligament leiomyomas are uncommon but when they occur can present in varying degrees of bladder and bowel obstruction. A definite diagnosis the broad leiomyoma was made after histopathological report specimen obtained operating patient. 45 years old female had a history pain abdomen increase abdominal girth for 6 months. On basis CT scan left adnexal mass made. She advised surgery subseque...

Background: Leiomyomas are by far the commonest uterine neoplasms in female reproductive age group. Giant leiomyomas quite scarce and when longstanding tend to undergo various degenerations owing decreased blood supply which on imaging may simulate malignancy compromised imaging.Case Presentation: We present a case of 48-year-old post-menopausal multiparous woman complaining intermittent lower ...

Introduction: Different types of soft tissue tumors affect the gastrointestinal tract. Among them are leiomyomas, which relatively uncommon. They commonly asymptomatic masses and discovered incidentally on radiological scans. Pathological examination is mainstay diagnosis. Surgery remains cornerstone management.

Gastrointestinal stromal tumors (GISTs) are the most common nonepithelial neoplasm of the gastrointestinal tract and show a predilection for the stomach. Most are detected because of symptoms, but some are incidental findings at autopsy or surgery for other reasons. Incidental GISTs tend to be smaller at diagnosis, but even small (<1 cm) GISTs have been shown to harbor activating KIT mutations ...