BACKGROUND Recent evidence from developed and developing countries shows clear clinical and public health benefit to starting antiretroviral therapy (ART) earlier. While discussions about when to start ART have often focused on the clinical risks and benefits, the main issue is one of fair limit-setting. We applied a human rights framework to assess a policy of early treatment initiation accord...

Nineteen mutants that are conditional for both the ability to regain motility following deciliation and the ability to grow were isolated. The mutations causing slow growth were placed into five complementation groups. None of the mutations appears to affect energy production as all mutants remained motile at the restrictive temperature. In three complementation groups protein synthesis and the...

A continuing theme over recent months has been to reaffirm the potentially harmful effects of specific interventions. The Canadian Clinical Trials Group published the third paper from their investigations into the effects of a restrictive strategy of blood transfusion (see paper report) [1]. Their restrictive strategy sets the threshold for packed red cell transfusion at haemoglobin levels < 8 ...

The Human Fertilisation and Embryology Authority's (HFEA) recent restrictive recommendations on sex selection have highlighted the need for consideration of the plausibility of ethical arguments against sex selection. In this paper, the author suggests a parental virtues approach to some questions of reproductive ethics (including sex selection) as a superior alternative to an exclusively harm ...

Since Bleam's (2000) initial claim that capturing clitic climbing patterns in Romance requires the descriptive power of set-local MCTAG (Weir, 1988), alternative approaches to relaxing tree-locality restrictions have been developed, including delayed tree-local MCTAG (Chiang and Scheffler, 2008), which, unlike set-local MCTAG, is weakly equivalent to standard TAG. This paper compares 2-delayed ...

Some patients requiring long-term intermittent or continuous mechanical ventilation can be safely treated at home with less cost and greater patient and family satisfaction. This is supported by experience with restrictive or obstructive respiratiroy disease patients in a respirator home care program from 1973 through 1979; some were followed for over four years. Moreover, risk is low as judged...

BACKGROUND Improvement in PFT after bronchodilators is characteristic of obstructive airway diseases such as COPD. However, improvement in patients with restrictive pattern is occasionally seen. We aim to determine the clinical significance of a bronchodilator responsive restrictive defect. METHODS Patients with restrictive spirometry and a bronchodilator study were identified at the Universi...

INTRODUCTION Vertical-banded gastroplasty, a technique that is commonly performed in the treatment of morbid obesity, represents a nonadjustable restrictive procedure which reduces the volume of the upper stomach by a vertical stapler line. In addition, a textile or silicone band restricts food passage through the stomach. CASE PRESENTATION A 71-year-old woman presented with a severe gastric ...