1. Summary 2. Overview 3. Background: General Lead Discovery Trends, 1990-Present 3.1. Overview 3.2. Drug Discovery for Huntington’s Disease 3.3. NIH Anticonvulsant Screening Program. 3.4. Aurora Biosciences and the Cystic Fibrosis Foundation 3.5. Best Practices 4. ALS: Clinical Characteristics and Experimental resources 4.1. Overview 4.2. Trends in ALS Basic Research 4.3. Clinical Development ...

About 8000 genes encode membrane proteins in the human genome. The information about their druggability will be very useful to facilitate drug discovery and development. The main problem, however, consists of limited structural and functional information about these proteins because they are difficult to produce biochemically and to study. In this paper we describe the strategy that combines Ce...