Abstract Background Monoclonal antibodies that inhibit the proprotein convertase subtilisin/kexin type 9 (PCSK9) reduce low-density lipoprotein cholesterol (LDLc) by 55%, regardless of baseline treatments, and are supposed to have a homogenous effect. We tested possible gender differences in large multicenter registry real-world patients treated with PCSK9 inhibitors. Methods Multicentre retros...

BACKGROUND The prevalence of cardiovascular disease is projected to be 38.7% for the USA in 2020, including coronary heart disease at 8.6% and stroke at 3.6%. In South Africa (SA), premature deaths due to heart and blood vessel diseases in people of working age (35 - 64 years) have been predicted to increase by 41% between 2007 and 2030, with enormous negative economic impact. Atherosclerosis u...

Although the debate about when, whom, and how to treat adults with elevated low-density-lipoprotein cholesterol (LDLc) is essentially over because of a huge amount of data generated by large, clinical end-point, placebo-controlled trials with HMG CoA reductase inhibitors (statins),1–3 the issue in children and adolescents is not yet settled. In this issue of Circulation, Rodenburg and colleague...

Background: Due to the high failure rate observed in the clinical treatment of morbid obesity an increase in bariatric surgery indications, as an alternative for the control of obesity and comorbidities, is noticeable. Aim: To evaluate the performance of type 2 diabetes mellitus, high blood pressure and dyslipidemia in patients submitted to Roux-en-Y gastric bypass in late follow-up. Method...

After much speculation, to the point of congressional involvement, regarding the reasons for the delay in reporting the results of a relatively small trial of carotidartery imaging in patients with familial hypercholesterolemia (FH), a brief top-line synopsis was released this year on January 14 (1 ). The study, called ENHANCE (Effect of Combination Ezetimibe and High-Dose Simvastatin versus Si...

We ell-trained endurance athletes have average high density lipoprotein cholesterol (HDL-C) concentrations 20 mg/dl or 4050% higher than those of sedentary men.1-3 Triglyceride levels characteristically are 20% lower in these athletes, and low density lipoprotein cholesterol (LDLC) may be 5-10% less.12 Since skeletal muscles neither secrete nor directly catabolize lipoproteins, what links muscu...

To the Editor: We read with concern the recent paper by Fallest-Strobl, Olafsdottir, Wiebe, and Westgard (1) in which the authors state, “. . . the NCEP recommendations fail to adequately consider the quality control requirements necessary to detect medically important systematic errors.” We also note that Westgard, Petersen, and Wiebe (2) published a similar paper in 1991 questioning the adequ...

OBJECTIVES To investigate if urban Africans displayed lower levels of atheroprotective high-density lipoprotein cholesterol (HDLC) when presenting with communicable versus non-communicable forms of heart disease (HD) as both acute infection and chronic inflammation reduce HDLC levels. DESIGN Hospital registry of 5328 de novo cases of HD over a 3-year period. SETTING Cardiology Unit, Baragwa...

Background and Objective: In development and progression of atherosclerosis, hypercholesterolemia plays a vital role. Prosopis cineraria L. Druce family, Fabaceae, Leguminosae reported to have various pharmacological potential. Hence, the aim of the present investigation was to evaluate its anti-hyperlipidemic potential against High Fat Diet (HFD) induced hyperlipidemia in the laboratory rat. M...

BACKGROUND Diabetes is a multifactorial disease characterized by severalmetabolic disorders. Its prevalence rate in Gaza Strip is alarming. OBJECTIVE To describe the clinical and biochemical features of patients with Type 2 diabetes in Gaza Governorate. METHODS Data were obtained through a questionnaire interview, patients' records and of 99 type 2 diabetes patients and 95 healthy individua...