The effect of latrunculin A, an inhibitor of actin cross-linking, on exocytosis in PC12 cells was investigated with single cell amperometry. This analysis strongly suggests that the actin cytoskeleton might be involved in regulating exocytosis, especially by mediating the constriction of the pore. In an extended kiss-and-run release mode, actin could actually control the fraction of neurotransm...

Disruption of microfilaments in human umbilical vein endothelial cells (HUVEC) with cytochalasin D (cytD) or latrunculin A (latA) resulted in a 3.3- to 5.7-fold increase in total synthesis of prostaglandin E(2) (PGE(2)) and a 3.4- to 6.5-fold increase in prostacyclin (PGI(2)) compared with control cells. Disruption of the microtubule network with nocodazole or colchicine increased synthesis of ...

In mammals, memory formation and stabilization requires polymerization of actin. Here, we show that, in the honeybee, inhibition of actin polymerization within the brain centres involved in memory formation, the mushroom bodies (MBs), enhances associative olfactory memory. Local application of inhibitors of actin polymerization (Cytochalasin D or Latrunculin A) to the MBs 1 h before induction o...

Abbreviations used in this paper: ARM, armadillo; Ccdc155, coiled-coil domaincontaining protein 155; GI, GenInfo Identifier; GUS, -glucuronidase; Hpa, Hyaloperonospora arabidopsidis; IP, immunoprecipitation; KASH, Klarsicht/ ANC-1/Syne-1 homology; KD, knockdown; KO, knockout; LatB, Latrunculin B; LINC, linker of nucleoskeleton and cytoskeleton; Lrmp, lymphoid-restricted membrane protein; NE, n...