Innovative algorithms have been developed during the past decade for simulating Newtonian physics for macromolecules. A major goal is alleviation of the severe requirement that the integration timestep be small enough to resolve the fastest components of the motion and thus guarantee numerical stability. This timestep problem is challenging if strictly faster methods with the same all-atom reso...

  Background: Vitex agnus - castus extract (Vitex) is available in dosage forms for female disorders treatment. This extract has shown controversial effects against seizures induced by Maximal electroshock (MES) or pentylenetetrazole (PTZ).   Objective: In the present study the anti-seizure activity of Vitex against acquisition of amygdala kindling was evaluated in male rats.   Methods: Intact ...

Obsessive-compulsive disorder (OCD) is a psychiatric disorder manifested by thoughts and impulses that produce anxiety and result in patients performing repetitive rituals. Treatment generally consists of cognitive behavioral intervention and serotonin reuptake inhibitors. Up to 40% of patients will have functional impairment that significantly affects their quality of life. In the late 1990’s,...

introduction: several studies have evaluated the inflammatory reaction triggered by epiphany (eph), a contemporary endodontic sealer. however, they used conventional parameters, which need additional analysis to better understand the reactions induced by this sealer compared to other traditional sealers. methods and materials: the intensity and time span of tissue irritations for three endodont...

OBJECTIVE To verify the influence of moderate- or high-pressure balloon inflation during primary coronary stent implantation for acute myocardial infarction. METHODS After successful coronary stent implantation, 82 patients were divided into 2 groups according to the last balloon inflation pressure: group 1 (> or = 12 to < 16 atm) and group 2 (> or = 16 to 20 atm), each with 41 cases. All pat...

INTRODUCTION We evaluated single institution toxicity outcomes after post-prostatectomy radiotherapy (PPRT) via image-guided intensity-modulated radiation therapy (IG-IMRT) with implanted fiducial markers following national eviQ guidelines, for which late toxicity outcomes have not been published. METHODS Prospectively collected toxicity data were retrospectively reviewed for 293 men who unde...

BACKGROUND We aimed to evaluate a new drug-free fully bioresorbable lactic acid-based scaffold designed to allow early dismantling synchronized with artery wall healing in comparison with a bare metal stent (BMS). METHODS AND RESULTS Twenty-three BMS (3.0×12 mm) and 36 lactic acid-based bioresorbable scaffolds (BRS, 3.0×11 mm) were implanted in porcine coronary arteries. QCA and optical coher...

We examine if cell adhesion to the surface of an intraocular lens varies with the period of implantation. Samples of extracted intraocular lenses (IOLs) that had been implanted during 1987-2000 (n=72, early group) and those during 2001–2014 (n=182, late group) were included. IOLs were stained with hematoxylin and eosin and grouped according to the presence or absence of cellular deposits on the...