Takotsubo cardiomyopathy can be divided in apical ballooning, mid-ventricular ballooning, and rarely in basal ballooning. The role of left anterior descending coronary artery is still in debate. Spasms, myocardial bridging and recurrent segment (wrap-around) LAD have been described in takotsubo cardiomyopathy. 8 patients (4 females, mean age 74.3 ± 9.7 years) with typical apical ballooning in 4...

The coronary vasculature located distal to a chronic occlusion (collateral-dependent) has been shown to exhibit altered reactivity to vasoactive agonists. Thus we evaluated effects of chronic coronary artery occlusion on vasomotor responsiveness of collateral-dependent arteries isolated from a canine model of Ameroid occlusion of the left circumflex (LCX) coronary artery. We compared in vitro r...

We compared myocardial infarct size produced by permanent occlusion of the middle left anterior descending (LAD) or circumflex (LCx) coronary artery in the anesthetized dog. The dogs were killed 3-10 days later, and the occluded coronary bed was visualized by postmortem arteriography. The outlines of the infarct and occluded bed were marked on tracings of weighed left ventricular (LV) rings and...

We compared myocardial infarct size produced by permanent occlusion of the middle left anterior descending (LAD) or circumflex (LCx) coronary artery in the anesthetized dog. The dogs were killed 3-10 days later, and the occluded coronary bed was visualized by postmortem arteriography. The outlines of the infarct and occluded bed were marked on tracings of weighed left ventricular (LV) rings and...

OBJECTIVES This study investigated the association between arterial remodeling and geographic distribution of cardiac allograft vasculopathy (CAV), and outcomes after heart transplantation. BACKGROUND CAV is characterized by a combination of coronary intimal thickening and pathological vessel remodeling, which varies at different locations in coronary arteries. METHODS In 100 transplant rec...

Nitroglycerin (TNG) causes a prolonged dilatation of coronary collaterals. To demonstrate a functional significance of this dilatation we measured the effect of TNG on myocardial contractile force in dogs 2(1/2)-4 wk after the left anterior descending coronary artery (LAD) had been embolized in closed-chest animals. Development of collaterals was documented by angiography. Via a left thoracotom...

Recently, logical analysis of data (LAD) using a classifier based on a linear combination of patterns has been introduced, providing high classification accuracy and pattern-based interpretability on classification results. However, it is known that most of LAD-based multi-classification algorithms have conflicts between classification accuracy and computational complexity because they are base...

We examined the response of left coronary arteries to intracoronary injection of acetylcholine (ACh) 50 micrograms in 74 patients by measuring the diameter changes with a videodensitometric analysis system. Patients with angiographically normal coronary arteries were subdivided into a younger group of 26 patients (age, 9-29 years) and an older group of 23 patients (age, 31-68 years). In the you...

Leukocyte adhesion deficiency type I (LAD-I) is a rare, inherited immunodeficiency with defect in the recruitment of leukocyte to the site of inflammation. Patients with severe LAD-I have absent or markedly reduced expression of CD18 and CD11. Here we report clinical profile of 7 cases of LAD-I diagnosed at our center over a period of 3 years. Recurrent skin and mucous membrane infections wer...

(A) Prominent filling defect at the floor of the proximal left anterio septal perforating branch. Left main coronary artery normal. Left c wire biased down septal perforating branch of the LAD. Thrombus Far field of the vessel (9 to 1 o’clock positions) drops out and is n erosclerotic plaque in the LAD—visualized by OCT at the 9 to 10 o branch. (F) Further ruptured atherosclerotic plaque in the...