نتایج جستجو برای: lactamase oxa
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BACKGROUND Acinetobacter baumannii is an important hospital-acquired pathogen in healthcare facilities that frequently causes bacteraemia and ventilator-associated pneumonia in intensive care units. Acinetobacter baumannii can be isolated from various sites in the hospital environment like medical equipment, bed linen, medical personnel and indwelling catheters. It is difficult to treat A. baum...
INTRODUCTION Recently Acinetobacter baumannii isolates have emerged as a problematic infectious agent that causes meningitis in neurosurgical patients. Colistin has been used successfully for the treatment of A. baumannii meningitis but colistin resistant isolates have been reported worldwide. CASE PRESENTATION Two isolates of A. baumannii were cultured during a five-day period from cerebrosp...
From February to November 1997, 29 inpatients at Ramón y Cajal Hospital, Madrid, Spain, were determined to be either colonized or infected with imipenemand meropenem-resistant Acinetobacter baumannii (IMRAB) strains (MICs, 128 to 256 mg/ml). A wide antibiotic multiresistance profile was observed with IMRAB strains. For typing IMRAB isolates, pulsed-field gel electrophoresis was used. For compar...
Supplementary data at JAC Online). An additional promoter was predicted by Softberry BPROM promoter prediction and consisted of the 235 box of IS18 and a 210 box separated by 13 bp (Figure S1, available as Supplementary data at JAC Online). 10 Interestingly , the TTCAAT 235 box identical to that from Baz (bla OXA-228) was adjacent to the left inverted repeat. OXA-228-like expression in isolate ...
To the Editor—The emergence of New Delhi metallo-beta-lactamase–1 (NDM1) in India, Pakistan, and the UK has sparked great fear of the threat posed by resistant microbial strains and by the use of antibiotics worldwide [1]. Thus far, NDM-1 carbapenemase has been detected in several countries in a diverse group of bacteria. Acinetobacter baumannii has emerged as one of the most troublesome pathog...
Bacterial resistance to β-lactams may rely on acquired β-lactamases encoded by class 1 integron-borne genes. Rearrangement of integron cassette arrays is mediated by the integrase IntI1. It has been previously established that integrase expression can be activated by the SOS response in vitro, leading to speculation that this is an important clinical mechanism of acquiring resistance. Here we r...
To the Editor—Resistance to carbapenems in Enterobacteriaceae is emerging worldwide [1, 2]. The enzymes that are responsible for the resistance are mostly clavulanic acid–inhibited carbapenemase (KPC), metallo-b-lactamases (Verona integron-related metallo-blactamase [VIM], IMP-type carbapenemases, New Delhi metallo-b-lactamase), and b-lactamases of the OXA-48 type [3]. The bacterial strains tha...
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