Enterovirus-71 (EV71) is a viral pathogen that causes severe cases of hand, foot and mouth disease (HFMD) among young children, with significant mortality. Effective vaccines against HFMD are urgently required. Several EV71 virus-like particle (VLP) vaccine candidates were found to be protective in the neonatal mouse EV71 challenge model. However, to what extent the VLP vaccine protects suscept...

Abstract In the past few years, emergence of pre-training models has brought uni-modal fields such as computer vision (CV) and natural language processing (NLP) to a new era. Substantial works have shown that they are beneficial for downstream tasks avoid training model from scratch. So can pre-trained be applied multi-modal tasks? Researchers explored this problem made significant progress. Th...

BACKGROUND Japanese encephalitis virus (JEV) is the most important cause of epidemic encephalitis in most Asian regions. There is no specific treatment available for Japanese encephalitis, and vaccination is the only effective way to prevent JEV infection in humans and domestic animals. The purpose of this study is to establish a new mammalian cell line stably and efficiently expressing virus-l...

Optical Wireless Communication (OWC) is being explored for application in the next-generation broadcasting networks, where possessing accurately determined user locations becomes increasingly important. Received signal strength (RSS) Visible Light Positioning (VLP)-based localisation systems aim to deliver these centimetre-level location data at a low cost by featuring but single photodiode (PD...

Infection by human papilloma virus (HPV) attracted attention in connection with cervical cancer in humans (zur Hausen, 1996). HPV type 16 alone accounts for approximately 50% of all cases of cervical cancer. The virus icosahedral capsid is composed of the L1 major and the L2 minor proteins. L1 alone has the capacity to self-assemble into virus-like particles (VLPs) without participation of L2 o...

LEVEL: ADVANCED G ardasil (a registered trademark of Merck and Co., Inc., www. merck.com) is the first vaccine approved for women aged 9–26 years old in prevention of cervical cancer and genital warts as well as vulvar and vaginal precancerous legions. The vaccine contains noninfectious virus-like particles (VLPs) corresponding to HPV types 6, 11, 16, and 18. It is produced by recombinantly exp...

High vertical laryngeal position (VLP), pharyngeal constriction, and laryngeal compression are common features associated with hyperfunctional voice disorders. The present study aimed to observe the effect on these variables of different semioccluded vocal tract postures in 20 subjects diagnosed with hyperfunctional dysphonia. During observation with flexible endoscope, each participant was ask...

Hepatitis E virus (HEV) is a human pathogen that causes acute hepatitis. When an HEV capsid protein containing a 52-amino-acid deletion at the C terminus and a 111-amino-acid deletion at the N terminus is expressed in insect cells, the recombinant HEV capsid protein can self-assemble into a T=1 virus-like particle (VLP) that retains the antigenicity of the native HEV virion. In this study, we u...

Deformity correction and internal fixation during surgical treatment of Charcot Arthropathy (CA) requires strong implants capable of ensuring long-term stability and function of the foot. The purpose of this study was to determine the construct shear strength of the newly developed VLP Locking Osteopenia Screw (Smith & Nephew, Inc., Memphis, TN, USA), as compared to the VLP Locking Cortical Scr...

Rotaviruses are large, complex icosahedral particles consisting of three concentric capsid layers. When the innermost capsid protein VP2 is expressed in the baculovirus-insect cell system it assembles as core-like particles. The amino terminus region of VP2 is dispensable for assembly of virus-like particles (VLP). Coexpression of VP2 and VP6 produces double layered VLP. We hypothesized that th...