background: leishmaniasis has been identified as a major public health problem in tropical and sub-tropical countries. the present study was aimed to investigate antileishmanial effects of various extracts of berberis vulgaris also its active com-poenent, berberine against leishmania tropica and l. infantum species on in vitro ex-periments. methods : in this study in vitro antileishmanial activ...

background: sensitive and glucantime (ma) resistance leishmania tropica are referred to those isolates, which are responsive, or non-responsive to one or two full courses of treatment by ma systematically and/or intra-lesionally, respectively. in this study, we evaluated the antileishmanial activity of biogenic selenium nanoparticles (se nps) alone and in combination with ma against sensitive a...

In September 2012, a cutaneous leishmaniasis outbreak began among Syrian refugees in Lebanon. For 948 patients in whom leishmaniasis was not confirmed, we obtained samples for microscopic confirmation and molecular speciation. We identified Leishmania tropica in 85% and L. major in 15% of patients. After 3 months of megulamine antimonite therapy, patients initial cure rate was 82%.

BACKGROUND Leishmaniasis is a protozoan disease cause by Leishmania genus. Anthroponotic and zoonotic cutaneous leishmaniasis are endemic in Iran. The aim of this study was to identify the causative agent of cutaneous leishmaniasis by mini-exon gene in five regions of Khuzestan Province, southwest of Iran. METHODS From 2007 to 2008 in this cross-sectional study, cutaneous samples were collect...

we describe a case of visceral leishmaniasis (vl) due to leishmania tropica in a 50-year-old iranian man lived in a vl-endemic area in southwest of iran. the patient presented with a 3-month history of fever and splenomegaly. clinical signs and serological findings were suggestive of vl. spleen biopsy was taken from the patient and intracellular forms of leishmania amastigotes was seen in giems...

In a former communication one of us (Row, 1922) had pointed out that the flagellate leptomonad forms of Leishmania tropica reverted to the leishmania O-bodies and these made their appearance in the condensation fluid of NNN culture tubes inoculated with the parasite 2 to 3 weeks previously. These were described as the O-bodies, or resistant forms, and it is the presence of these in old cultures...

background: the mechanisms of virulence and species differences of leishmania parasites are under the influence of gene expression regulations at posttranscriptional stages. in iran, l. major and l. tropica are known as principal agents of cutaneous leishmaniasis, while l. infantum causes visceral leishmaniasis. methods: as a preliminary study, we compared the proteome mapping of the above thre...

Considering the different clinical symptoms of leishmaniasis in Iran, and the wide distribution of its agent and the little information in this regard, this study was performed to characterize the responsible variants using monoclonal antibodies. A total of 156 isolates of Leishmania from patients with cutaneous leishmaniasis and one isolate from rat were characterized using the standard monoc...