نتایج جستجو برای: knock out serum replacement
تعداد نتایج: 1209402 فیلتر نتایج به سال:
Glutathione peroxidase (GSHPx) is a critical intracellular enzyme involved in detoxification of hydrogen peroxide (H(2)O(2)) to water. In the present study we examined the susceptibility of mice with a disruption of the glutathione peroxidase gene to the neurotoxic effects of malonate, 3-nitropropionic acid (3-NP), and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP). Glutathione peroxidase ...
Pathogenic Yersinia spp. translocate the effectors YopT, YopE, and YopO/YpkA into target cells to inactivate Rho family GTP-binding proteins and block immune responses. Some Yersinia spp. also secrete the Rho protein activator cytotoxic necrotizing factor-Y (CNF-Y), but it has been unclear how the bacteria may benefit from Rho protein activation. We show here that CNF-Y increases Yop translocat...
This paper presents a number of new theoretical results for replication of barrier options through a static portfolio of European put and call options. Our results are valid for options with completely general knock-out/knock-in sets, and allow for timeand state-dependents volatility as well as discontinuous asset dynamics. We illustrate the theory with numerical examples and discuss the practi...
A leading theory holds that neurodevelopmental brain disorders arise from imbalances in excitatory and inhibitory (E/I) brain circuitry. However, it is unclear whether this one-dimensional model is rich enough to capture the multiple neural circuit alterations underlying brain disorders. Here, we combined computational simulations with analysis of in vivo two-photon Ca2+ imaging data from somat...
The fragmentation of one-nucleon knock-out strength at low energies is considered from the viewpoint of the two particle-one hole ~and two holeone particle! response propagator. The aim is to deal with particleparticle ~and hole-hole! as well as particle-hole collectivity simultaneously. This is achieved on a TammDancoff level by the so-called Faddeev approximation of the 2p1h propagator. Resul...
In a bounded open region of the d dimensional Euclidean space we consider a Brownian motion which is reborn at a fixed interior point as soon as it reaches the boundary. It was shown that in dimension one coupled paths starting at different points but driven by the same Brownian motion either collapse with probability one or never meet. In higher dimensions, for convex or polyhedral regions the...
Whereas the mechanisms involved in autophagosome formation have been extensively studied for the past 2 decades, those responsible for autophagosome-lysosome fusion have only recently begun to garner attention. In this study, we report that the multisubunit BORC complex, previously implicated in kinesin-dependent movement of lysosomes toward the cell periphery, is required for efficient autopha...
In this work we redefine the concept of biological importance and how to compute it, based on a model of complex networks and random walk. We call this new procedure, theoretical knock-out (KO). The proposed method generalizes the procedure presented in a recent study about Oral Tolerance. To devise this method, we make two approaches: algebraically and algorithmically. In both cases we compute...
One of the factors that affects the efficiency and lifetime of spark ignited internal combustion engine is “knock”. Knock sensor is a commonly used to detect this phenomenon. However, noise, limits detection accuracy of this sensor. In this study, Empirical Mode Decomposition (EMD) method is introduced as a fully adaptive signal-based analysis. Then, based on weighting decomposition...
Vesicular (v)- and target (t)-SNARE proteins assemble in SNARE complex to mediate membrane fusion. Tetanus neurotoxin-insensitive vesicular-associated membrane protein (TI-VAMP/VAMP7), a vesicular SNARE expressed in several cell types including neurons, was previously shown to play a major role in exocytosis involved in neurite growth in cultured neurons. Here we generated a complete constituti...
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