Introduction Chronic pain and stiffness occurring after total knee arthroplasty are frustrating for both the patient and the surgeon. After total knee arthroplasty (TKA), there is a relatively small group of patients who develop a painful joint with suboptimal range of motion (ROM) despite optimal surgical technique and good radiographic appearance. Arthrofibrosis, for the most part, is an unco...

ammalian sex-determining factors with homology to DNA binding proteins are required for splicing, according to a study by Paolo SassoneCorsi and coworkers at the Université Louis Pasteur (Strasbourg, France). Examination of high mobility group (HMG) domain containing SRY and Sox proteins demonstrated a surprising but clear association with splicing complexes. SRY, the testis-determining factor ...

BACKGROUND Rollover footwear is assumed to provide an enhanced surface over which the body can roll more easily. The aim of this study was to investigate the effects of rollover footwear on the rollover function of walking. METHODS Twenty subjects walked in three conditions: (i) a MBT shoe (Masai Barefoot Technology) characterized by a stiff sole rounded in the anterior-posterior direction; (...

Objectives: To examine the feasibility and within-session reliability of Myoton technology to measure muscle stiff-ness objectively in people with Parkinson’s disease an outpatient settingDesign: An exploratory quantitative study design was used.Setting: The conducted physiotherapy department a Teaching Hospital Ghana. Par-ticipants were recruited from three sites.Participants: Thirty adults ov...

Nuclear export receptor CRM1 binds highly variable nuclear export signals (NESs) in hundreds of different cargoes. Previously we have shown that CRM1 binds NESs in both polypeptide orientations (Fung et al., 2015). Here, we show crystal structures of CRM1 bound to eight additional NESs which reveal diverse conformations that range from loop-like to all-helix, which occupy different extents of t...