The functional variant of the Klotho "KL-VS" stretch, which includes six polymorphisms in linkage disequilibrium, is reportedly associated with healthy aging and longevity in European and American populations. Among Asian populations, this variant has been observed in the Indian population but not in the Iranian population. An association between KL-VS polymorphism and aging has not been report...

We establish a new class of relations among the multiple zeta values ζ(k1, . . . , kl) = ∑ n1>···>nl≥1 1 n k1 1 · · ·n kl k , which we call the cyclic sum identities. These identities have an elementary proof, and imply the “sum theorem” for multiple zeta values. They also have a succinct statement in terms of “cyclic derivations” as introduced by Rota, Sagan and Stein. In addition, we discuss ...

BACKGROUND AND AIM Pancreatic juice cytology (PJC) is considered optimal for differentially diagnosing pancreatic masses, but the accuracy of PJC ranges from 46.7% to 93.0%. The aim of this study was to evaluate the clinical impact of measuring the KL-6 concentration of pancreatic juice for diagnosing pancreatic masses. METHODS PJC and the KL-6 concentration measurements of pancreatic juice w...

This technical brief presents a numerical study regarding the required development length ðL 1⁄4 Lfd=HÞ to reach fully developed flow conditions at the entrance of a planar channel for Newtonian fluids under the influence of slip boundary conditions. The linear Navier slip law is used with the dimensionless slip coefficient kl 1⁄4 kl l=H ð Þ, varying in the range 0 < kl 1. The simulations were ...

Klotho is a recently identified antiaging gene. Brain endothelin-1 (ET1) is important in the regulation of blood pressure (BP). We hypothesized that silence of brain klotho potentiates cold-induced elevation of BP via the endothelin pathway. To silence brain klotho, we constructed adeno-associated virus (AAV) carrying rat klotho small interference hairpin RNA (KL-shRNA). AAV carrying ET1-shRNA ...

The p16(INK4a) tumour suppressor has an established role in the implementation of cellular senescence in stem/progenitor cells, which is thought to contribute to organismal ageing. However, since p16(INK4a) knockout mice die prematurely from cancer, whether p16(INK4a) reduces longevity remains unclear. Here we show that, in mutant mice homozygous for a hypomorphic allele of the α-klotho ageing-...

We present recent preliminary results from five decay channels. From the KL → π πγ channel, we extract form factors for the CP violating M1 direct photon emission amplitude and the fraction of the total decay amplitude that is due to direct emission. We have placed an upper limit on the KL → π πγ branching ratio, and preliminary measurements of the KL → πeνee and π → ee branching ratios are pre...

The Kullback-Leibler (KL) divergence is a fundamental equation of information theory that quantifies the proximity of two probability distributions. Although difficult to understand by examining the equation, an intuition and understanding of the KL divergence arises from its intimate relationship with likelihood theory. We discuss how KL divergence arises from likelihood theory in an attempt t...

Wereport a patient with KL-6-producing invasive thymoma.A 58-year-old man was admitted complaining of dyspnea and fatigability. Computedtomography of the chest revealed interstitial pneumoniaand an anterior mediastinal tumor. The tumor was surgically extirpated and diagnosed as invasive thymoma. Serum KL-6 levels later increased further and another tumor was found in the liver. That liver tumor...

υ(X,L) = lim sup k→∞ n! kn h(X,OX(kL)). If L is ample, or more generally nef and big, υ(L) = (L), the self-intersection number of L. The volume of a general big line bundle has been studied in [F] and [DEL]; in particular, υ(L) has been given the following geometric interpretation (Proposition 3.6 of [DEL]): Let (kL) [n] be the moving selfintersection number of kL, that is, the number of inters...