Reversible reactions are described in terms of kinetic cycles. From this description, two useful parameters arise: 1) average cycle duration and 2) average number of cycles. The latter applies to cycles with at least one unstable species. These parameters allow answering the question "How fast is a fast equilibrium?" in absolute and in relative terms, respectively. The general interest of the a...

In attempting to develop large-scaled metabolic models using general dynamic modeling methods, a large set of data, such as kinetics mechanisms and parameters, is required. It is difficult to obtain a complete set of rate equations and kinetic parameters. To solve the problem, we have proposed an algorithm which simulates a pathway model including dynamic kinetic parts and flux-based static par...