BACKGROUND Atypical hemolytic uremic syndrome associated with autoantibodies to complement factor H is an important cause of acute kidney injury; most patients require dialysis and are at risk of progressive renal failure. CASE CHARACTERISTICS 7 patients with gastrointestinal symptoms, acute kidney injury, thrombotic microangiopathy and elevated levels of anti-complement factor H antibodies. ...

objective: despite the huge efforts, chronic kidney disease (ckd) remains as an unsolved problem in medicine. many studies have shown a central role for transforming growth factor beta-1 (tgfβ-1) and its downstream signaling cascades in the pathogenesis of ckd. in this study, we have reanalyzed a microarray dataset to recognize critical signaling pathways controlled by tgfβ-1. materials and met...

Experimental and clinical studies analyzing the impact of AVF on cardiovascular and renal parameters, as well as outcomes, in kidney transplant recipients are lacking. On the other hand, it is not known whether AVF ligation after transplantation modifies hemodynamic parameters and kidney function. We report a case of a renal transplant recipient who developed an acute congestive heart failure a...

Relevance: Kidney functions in treating acute myeloblastic leukemia (AML) undergo serious effects, especially elderly patients. Chemotherapeutic drugs used to prepare for hematopoietic stem cell transplantation (HSCT) inevitably affect patients’ kidney function. Moreover, involutive changes the kidneys can physiologically decrease function.
 The study aimed evaluate function an patient wit...

Exchange proteins directly activated by cAMP [Epac(s)] were discovered more than a decade ago as new sensors for the second messenger cAMP. The Epac family members, including Epac1 and Epac2, are guanine nucleotide exchange factors for the Ras-like small GTPases Rap1 and Rap2, and they function independently of protein kinase A. Given the importance of cAMP in kidney homeostasis, several molecu...

Combined heart and kidney transplant has become an accepted therapy for patients with coexisting heart and kidney failure. This method, compared with single-organ transplant, has a better outcome. Here, we report the first successful combined heart and kidney transplant in Iran. The patient was a 36-year-old man with end-stage renal disease owing to IgA nephropathy, admitted to Masih Daneshvari...

world kidney day (wkd) is a joint initiative of the international society of nephrology (isn) and the international federation of kidney foundations (ifkf). seven years on from the first campaign, world kidney day (wkd) has turned into a global phenomenon. on march 13, 2014, medical professionals, government officials, the general public, celebrities and patients took action locally. in 2014, t...

With the advent of the high-throughput data production, recent studies of tissue-specific metabolic networks have largely advanced our understanding of the metabolic basis of various physiological and pathological processes. However, for kidney, which plays an essential role in the body, the available kidney-specific model remains incomplete. This paper reports the reconstruction and characteri...