نتایج جستجو برای: khartooran erg

تعداد نتایج: 7132  

2016
Dake Li Qi Fang Hongbo Yu

PURPOSE Dark adaptation can induce a rapid functional shift in the retina, and after that, the retinal function is believed to remain stable during the continuous dark exposure. However, we found that electroretinograms (ERG) b-waves gradually shifted during 24 hours' dark exposure in rodents. Detailed experiments were designed to explore this non-classical dark adaptation. METHODS In vivo ER...

2013
IOANNIS PANAGOPOULOS LUDMILA GORUNOVA BERNWARD ZELLER ANNE TIERENS SVERRE HEIM

Sequential combination of cytogenetics and RNA-sequencing (RNA-Seq) has been shown to be an efficient approach to detect pathogenetically important fusion genes in neoplasms carrying only one or a few chromosomal rearrangements. We performed RNA-Seq on an acute myeloid leukemia in a 2-year-old girl with the karyotype 46,XX,add(1)(p36), der(2)t(2;3)(q21;q21),del(3)(q21),der(10)t(1;10)(q32;q24),d...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2013
Ken Kron Dominique Trudel Vaijayanti Pethe Laurent Briollais Neil Fleshner Theodorus van der Kwast Bharati Bapat

PURPOSE To assess differentially methylated "landscapes" according to prostate cancer Gleason score (GS) and ERG oncogene expression status, and to determine the extent of polycomb group (PcG) target gene involvement, we sought to assess the genome-wide DNA methylation profile of prostate cancer according to Gleason score and ERG expression. EXPERIMENTAL DESIGN Genomic DNA from 39 prostate ca...

2017
Xiangju Liu Ming Xue

BACKGROUND Down's syndrome (DS) is a genetic disease with chromosome abnormality due to the increasing chromosome 21. This study focused on the clinical application value of ERG methylation level in blood of pregnant women as a biomarker in Down's syndrome. MATERIAL AND METHODS The sham group consisted of 210 nonpregnant women, the positive control group consisted of 33 women with a delivery hi...

Journal: :Blood 2011
Julie A I Thoms Yehudit Birger Sam Foster Kathy Knezevic Yael Kirschenbaum Vashe Chandrakanthan Georg Jonquieres Dominik Spensberger Jason W Wong S Helen Oram Sarah J Kinston Yoram Groner Richard Lock Karen L MacKenzie Berthold Göttgens Shai Izraeli John E Pimanda

The Ets-related gene (ERG) is an Ets-transcription factor required for normal blood stem cell development. ERG expression is down-regulated during early T-lymphopoiesis but maintained in T-acute lymphoblastic leukemia (T-ALL), where it is recognized as an independent risk factor for adverse outcome. However, it is unclear whether ERG is directly involved in the pathogenesis of T-ALL and how its...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2008
Outi R Saramäki Anna E Harjula Paula M Martikainen Robert L Vessella Teuvo L J Tammela Tapio Visakorpi

PURPOSE Our aim was to assess the frequency of ERG overexpression and TMPRSS2:ERG rearrangement in prostate cancer and their association with clinicopathologic variables and outcome. EXPERIMENTAL DESIGN The presence of the TMPRSS2:ERG rearrangement was studied by reverse transcription-PCR and fluorescence in situ hybridization in 19 prostate cancer xenografts and 7 prostate cancer cell lines....

Journal: :Cancer prevention research 2011
Yiwei Li Dejuan Kong Zhiwei Wang Aamir Ahmad Bin Bao Subhash Padhye Fazlul H Sarkar

The development of prostate cancer and its progression to castrate-resistant prostate cancer (CRPC) after antiandrogen ablation therapy are driven by persistent biological activity of androgen receptor (AR) signaling. Moreover, studies have shown that more than 50% of human prostate cancers overexpress ERG (v-ets avian erythroblastosis virus E26 oncogene related gene) due to AR-regulated TMPRSS...

2011
Franclim R. Ribeiro Paula Paulo Vera L. Costa João D. Barros-Silva João Ramalho-Carvalho Carmen Jerónimo Rui Henrique Guro E. Lind Rolf I. Skotheim Ragnhild A. Lothe Manuel R. Teixeira

A large percentage of prostate cancers harbor TMPRSS2-ERG gene fusions, leading to aberrant overexpression of the transcription factor ERG. The target genes deregulated by this rearrangement, however, remain mostly unknown. To address this subject we performed genome-wide mRNA expression analysis on 6 non-malignant prostate samples and 24 prostate carcinomas with (n = 16) and without (n = 8) TM...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2013
Alan Dal Pra Emilie Lalonde Jenna Sykes Fiona Warde Adrian Ishkanian Alice Meng Chad Maloff John Srigley Anthony M Joshua Gyorgy Petrovics Theodorus van der Kwast Andrew Evans Michael Milosevic Fred Saad Colin Collins Jeremy Squire Wan Lam Tarek A Bismar Paul C Boutros Robert G Bristow

BACKGROUND Preclinical data suggest that TMPRSS2-ERG gene fusions, present in about 50% of prostate cancers, may be a surrogate for DNA repair status and therefore a biomarker for DNA-damaging agents. To test this hypothesis, we examined whether TMPRSS2-ERG status was associated with biochemical failure after clinical induction of DNA damage following image-guided radiotherapy (IGRT). METHODS...

2012
Orla M. Casey Lei Fang Paul G. Hynes Wassim G. Abou-Kheir Philip L. Martin Heather S. Tillman Gyorgy Petrovics Hibah O. Awwad Yvona Ward Ross Lake Luhua Zhang Kathleen Kelly

Genomic rearrangements commonly occur in many types of cancers and often initiate or alter the progression of disease. Here we describe an in vivo mouse model that recapitulates the most frequent rearrangement in prostate cancer, the fusion of the promoter region of TMPRSS2 with the coding region of the transcription factor, ERG. A recombinant bacterial artificial chromosome including an extend...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید