Cytochrome c release and the mitochondrial permeability transition (PT), including loss of the transmembrane potential (Deltapsi), play an important role in apoptosis. Using isolated mitochondria, we found that recombinant Bax and Bak, proapoptotic members of the Bcl-2 family, induced mitochondrial Deltapsi loss, swelling, and cytochrome c release. All of these changes were dependent on Ca2+ an...

Emman Shubbar ([email protected]) Anikó Kovács ([email protected]) Shahin Hajizadeh ([email protected]) Toshima Z Parris ([email protected]) Szilard Nemes ([email protected]) Katrin Gunnarsdóttir ([email protected]) Zakaria Einbeigi ([email protected]) Per Karlsson ([email protected]) Khalil Helou ([email protected]...

INTRODUCTION The preservative benzalkonium chloride (BAK) is used to preserve several topical, intraocular pressure (IOP)-lowering glaucoma medications but can cause tolerability concerns that may lead to decreased adherence to treatment and ultimately diminish the effectiveness of IOP control. The study aimed to determine the efficacy and tolerability of BAK-free travoprost preserved with poly...

Purpose Benzalkonium chloride (BAK) is the most commonly used eye drop preservative. Benzalkonium chloride has been associated with toxic effects such as "dry eye" and trabecular meshwork degeneration, but the underlying biochemical mechanism of ocular toxicity by BAK is unclear. In this study, we propose a mechanistic basis for BAK's adverse effects. Method Mitochondrial O2 consumption rates...

Assessment of probiotic-supplementation on growth performance, lipid peroxidation, antioxidant capacity, and cecal microflora in broiler chickensSahar F. Deraz, Alaa E. Elkomy, Ashraf A. Khalil

Promotoren: Prof. ir. Learning efficient disambiguation / Khalil Sima'an. Thesis, Utrecht University-With summary in Dutch ISBN 90-73446-88-0 Subject headings: natural language processing/machine learning/probabilistic parsing.

1 1 2 Increased MMPs Expression and Decreased Contraction in the Rat Myometrium 3 during Pregnancy and in Response to Prolonged Stretch and Sex Hormones 4 5 6 Zongzhi Yin, Alaa A. Sada, Ossama M. Reslan, Neha Narula, 7 Raouf A. Khalil 8 9 10 Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, 11 Brigham and Women’s Hospital, and Harvard Medical School, Boston, M...

Purpose: Bax and Bak are regarded as key mediators for cytochrome c (Cyt c) release and apoptosis. Loss of Bax or Bak is often reported in human cancers and renders resistance of these cancerous cells to chemotherapy. Here, we investigated that phenylarsine oxide (PAO) could induce Bax/Bak-independent apoptosis. Experimental Design: Annexin V/propidium iodide (PI) staining, terminal deoxynucleo...