BACKGROUND Studies in the 1990s have found that periconceptional dietary folate, supplementation of folic acid or supplemental multivitamins containing folic acid, help prevent neural tube defect (NTDs) if taken at the right time. This literature review assesses the extant folic acid public health campaigns literature and identifies some common variables used in folic acid consumption campaign ...

BACKGROUND A decrease in folic acid and subsequent DNA hypomethylation may be involved in gastric carcinogenesis. Epidemiological and nutritional studies have indicated that folate status modulates the risk of developing cancers. AIMS To investigate whether folic acid plays an important role in the chemoprevention of gastric carcinogenesis induced by N-ethyl-N-nitrosoguanidine (ENNG) in beagl...

Several observations in Go have suggested that folic acid may have a role in the oxidation of tyrosine, although no specific function of the vitamin in the metabolism of this ammo acid has been established. Woodruff and Darby (1) and Woodruff et al. (2) found that tyrosyluria, the excretion of p-hydroxyphenyl metabolites of tyrosine, could be corrected in scorbutic guinea pigs, not only by asco...

background: several studies showed that elevated plasma homocysteine level is a risk factor for coronary artery disease (cad). a common polymorphism c677t of methylenetetrahydrofolate reductase (mthfr) gene is reported to be associated with decreased enzyme activity and increased blood homocysteine level. methods: this study evaluated the association between c677t polymorphism and blood homocys...

background: pregnancy associated osteoporosis (pao) can lead to serious difficulties such as fragility fractures, elongated back pain and height loss in affected women. soluble receptor activator of nuclear factor-kappa b ligand (srankl) to osteoprotegerin (opg) ratio is chosen as a bone metabolism equation in many bone diseases characterized by bone resorption, such as post-menopausal osteopor...

background: several studies have examined the effects of folic acid fortification on the occurrence of orofacial clefts. this study was carried out to evaluate the impact of flour fortification with folic acid on oral clefts in northern iran.   methods : in this hospital based study from march 2006 to september 2009, we screened the total number of live births at all hospitals in golestan provi...

This study documented the prevalence (proportion) of mothers taking folic as supplements or as fortified foods and explored the factors that determined whether folic acid was taken. A cross sectional analysis of the baseline data of mothers who participated in the Perth Infant Feeding Study was performed. A total of 587 mothers who delivered at the two hospitals in the study completed baseline ...

The benefit of the introduction of mandatory folic acid fortification of all flour products in the USA in 1998 has been amply demonstrated in a reduction of neural tube defect births. Doubt has been cast on the actual level of fortification and recent calculations have shown that the level of folic acid fortification is likely to have been over twice the amount mandated. The implication of this...

The present study investigated the effect of folic acid supplementation on the Notch signaling pathway and cell proliferation in rat embryonic neural stem cells (NSCs). The NSCs were isolated from E14-16 rat brain and grown as neurospheres in serum-free suspension culture. Individual cultures were assigned to one of 3 treatment groups that differed according to the concentration of folic acid i...